To elucidate the mechanisms influencing visual function recovery after optic neuritis (ON), this study employed a multicompartment diffusion weighted imaging (DWI) model to assess the role of optic radiation integrity and its relationship with retinal parameters, including automatic retinal oximetry and retinal nerve fiber layer (RNFL) thinning. Twenty-four patients with the first episode of acute unilateral ON were compared with 56 healthy volunteers with normal vision. Additionally, longitudinal analysis 3 and 6 months after ON was performed in 17 patients. Multivariate analysis of variance across baseline DWI metrics revealed a greater secondary partial volume fraction (f2) in patients. In the longitudinal analysis, a multivariate effect of time was observed only when adjusted for the affected side and time since onset; however, univariate post hoc tests were nonsignificant. An unadjusted model stratified according to clinical outcomes (best-corrected visual acuity [BCVA] and contrast sensitivity) indicated lower overall fractional anisotropy (FA) in patients with incomplete recovery. In the correlation analysis, baseline FA and oximetry (venous saturation and arteriovenous difference) predicted follow-up BCVA, whereas axial diffusivity predicted follow-up oximetry. In turn, baseline oximetry predicted follow-up RNFL thickness. In summary, DWI and retinal oximetry are both potential predictors of visual function outcomes after ON.

Behavioural and Social Neuroscience CEITEC Central European Institute of Technology Masaryk University Kamenice 753 5 62500 Brno Czechia

Department of Biomedical Engineering University Hospital Olomouc Olomouc Czechia

Department of Neurology Faculty of Medicine and Dentistry Palacký University Olomouc Olomouc Czechia

Department of Neurology University Hospital Olomouc Olomouc Czechia

Department of Neurology University Medicine Greifswald Greifswald Germany

Department of Neurosurgery Faculty of Medicine and Dentistry Palacký University Olomouc Olomouc Czechia

Department of Ophthalmology Military University Hospital Prague Prague Czechia

Department of Ophthalmology University Hospital Olomouc Olomouc Czechia

Department of Radiology University Hospital Olomouc Olomouc Czechia

Functional Imaging Unit Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany

NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada

Zobrazit více v PubMed

Beck, R. W. et al. Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial. PubMed

Jenkins, T. M. & Toosy, A. T. Optic neuritis: the eye as a window to the brain. PubMed

Benard-Seguin, E. & Costello, F. Optic neuritis: current challenges in diagnosis and management. PubMed

Galetta, K. et al. Treatment outcomes of first-ever episode of severe optic neuritis. PubMed

Chan, J. W. Recent advances in optic neuritis related to multiple sclerosis. PubMed

Montolío, A., Cegoñino, J., Garcia-Martin, E. & Pérez Del Palomar, A. Comparison of machine learning methods using spectralis OCT for diagnosis and disability progression prognosis in multiple sclerosis. PubMed PMC

Petzold, A. et al. Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis. PubMed

Galetta, S. L. et al. Acute optic neuritis. PubMed PMC

Palsson, O. et al. Retinal oximetry images must be standardized: a methodological analysis. PubMed

Einarsdottir, A. B., Olafsdottir, O. B., Hjaltason, H. & Hardarson, S. H. Retinal oximetry is affected in multiple sclerosis. PubMed

Drobnjak Nes, D. et al. Exploring retinal blood vessel diameters as biomarkers in multiple sclerosis. PubMed PMC

Svrčinová, T. et al. Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis—a pilot study. PubMed

Svrčinová, T. et al. Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis associated with multiple sclerosis in a 6-month follow-up. PubMed PMC

Alshowaeir, D. et al. Multifocal VEP assessment of optic neuritis evolution. PubMed

Basser, P. J., Mattiello, J. & LeBihan, D. MR diffusion tensor spectroscopy and imaging. PubMed PMC

Reich, D. S. et al. Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. PubMed PMC

Lobsien, D. et al. Whole-brain diffusion tensor imaging in correlation to visual-evoked potentials in multiple sclerosis: a tract-based spatial statistics analysis. PubMed PMC

Nguyen, M. N. L. et al. Early predictors of visual and axonal outcomes after acute optic neuritis. PubMed PMC

Jeurissen, B., Tournier, J.-D., Dhollander, T., Connelly, A. & Sijbers, J. Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data. PubMed

Zhang, H., Schneider, T., Wheeler-Kingshott, C. A. & Alexander, D. C. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. PubMed

Collorone, S. et al. Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event. PubMed PMC

Storelli, L. et al. Advanced diffusion-weighted imaging models better characterize white matter neurodegeneration and clinical outcomes in multiple sclerosis. PubMed

Behrens, T. E. J. et al. Characterization and propagation of uncertainty in diffusion-weighted MR imaging. PubMed

Labounek, R. PubMed PMC

Valošek, J. et al. Diffusion magnetic resonance imaging reveals tract-specific microstructural correlates of electrophysiological impairments in non-myelopathic and myelopathic spinal cord compression. PubMed PMC

Pelli, D. G., Robson, J. G. & Wilkins, A. J. J. The design of a new letter chart for measuring contrast sensitivity.

Thompson, A. J. et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. PubMed

Oldfield, R. C. The assessment and analysis of handedness: the Edinburgh inventory. PubMed

Ferris, F. L., Kassoff, A., Bresnick, G. H. & Bailey, I. New visual acuity charts for clinical research. PubMed

Kurtzke, J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). PubMed

Král, M. et al. Correlation between retinal oxygen saturation and the haemodynamic parameters of the ophthalmic artery in healthy subjects. PubMed PMC

Traustason, S. et al. Retinal oxygen saturation in patients with systemic hypoxemia. PubMed

Jenkinson, M., Beckmann, C. F., Behrens, T. E. J., Woolrich, M. W. & Smith, S. M. FSL. PubMed

Andersson, J. L. R., Skare, S. & Ashburner, J. How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. PubMed

Andersson, J. L. R. & Sotiropoulos, S. N. An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. PubMed PMC

Grabner, G. et al. Symmetric atlasing and model based segmentation: an application to the hippocampus in older adults. PubMed

de Groot, M. et al. Improving alignment in Tract-based spatial statistics: Evaluation and optimization of image registration. PubMed PMC

Warrington, S. et al. Concurrent mapping of brain ontogeny and phylogeny within a common space: Standardized tractography and applications. PubMed PMC

Warrington, S. et al. XTRACT—Standardised protocols for automated tractography in the human and macaque brain. PubMed PMC

Schmidt, P. et al. An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis. PubMed

Youngstrom, E. A. A primer on receiver operating characteristic analysis and diagnostic efficiency statistics for pediatric psychology: we are ready to ROC. PubMed PMC

Backner, Y. et al. Anatomical wiring and functional networking changes in the visual system following optic neuritis. PubMed PMC

Kolbe, S. C. et al. Serial diffusion tensor imaging of the optic radiations after acute optic neuritis. PubMed PMC

Kuchling, J. et al. Comparison of probabilistic tractography and tract-based spatial statistics for assessing optic radiation damage in patients with autoimmune inflammatory disorders of the central nervous system. PubMed PMC

Tur, C. et al. Longitudinal evidence for anterograde trans-synaptic degeneration after optic neuritis. PubMed PMC

Gajamange, S. et al. Fibre-specific white matter changes in multiple sclerosis patients with optic neuritis. PubMed PMC

Kolbe, S. et al. Diffusion tensor imaging of the optic radiations after optic neuritis. PubMed PMC

Pawlitzki, M. et al. MS optic neuritis-induced long-term structural changes within the visual pathway. PubMed PMC

Raz, N., Bick, A. S., Ben-Hur, T. & Levin, N. Focal demyelinative damage and neighboring white matter integrity: an optic neuritis study. PubMed

Horbruegger, M. et al. Anatomically constrained tractography facilitates biologically plausible fiber reconstruction of the optic radiation in multiple sclerosis. PubMed PMC

Ngamsombat, C. et al. Axonal damage in the optic radiation assessed by white matter tract integrity metrics is associated with retinal thinning in multiple sclerosis. PubMed PMC

Behrens, T. E. J., Berg, H. J., Jbabdi, S., Rushworth, M. F. S. & Woolrich, M. W. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?. PubMed PMC

Dayan, M. et al. Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography. PubMed PMC

Honnedevasthana Arun, A., Connelly, A., Smith, R. E. & Calamante, F. Characterisation of white matter asymmetries in the healthy human brain using diffusion MRI fixel-based analysis. PubMed

Scheel, M. et al. Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: a combined optical coherence tomography and diffusion tensor imaging study. PubMed

Winklewski, P. J. et al. Understanding the physiopathology behind axial and radial diffusivity changes—What do we know?. PubMed PMC

Jakimovski, D. et al. Multiple sclerosis.