In this study, we present the synthesis of polyvinylidene fluoride (PVDF) nanofibers functionalized with an acrylic-β-cyclodextrin (β-CD-Acr) polymer as advanced adsorptive material for pharmaceutical removal from water. The modified nanofibers (NFs) demonstrated superior adsorption performance towards the model compound pimavanserin, with an equilibrium adsorption capacity of 56.2 mg/g compared to 34.2 mg/g for the β-CD-Acr polymer alone. The maximum uptake capacity also nearly doubled (113.6 mg/g vs. to 54.8 mg/g) highlighting the benefits of using the nanofiber support. The versatility of this polymer allows it to be polymerized onto various substrates, making it a promising candidate for large-scale applications. The results suggest that this innovative adsorptive nanofiber system could play a crucial role in combating water pollution globally, offering an effective and scalable solution for the removal of hazardous pharmaceuticals from wastewater.

Department of Chemistry and Technology of Functional Materials Faculty of Chemistry Gdańsk University of Technology 11 12 Narutowicza Street 80 233 Gdańsk Poland

Faculty of Mechatronics Informatics and Interdisciplinary Studies Technical University of Liberec Studentská 1402 2 461 17 Liberec Czech Republic

Institute for Nanomaterials Advanced Technologies and Innovation Technical University of Liberec Studentská 1402 2 461 17 Liberec Czech Republic

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Damania, R., Desbureaux, S., Rodella, A. S., Russ, J. & Zaveri, E.

Rivera-Utrilla, J., Sánchez-Polo, M., Ferro-García, M. Á., Prados-Joya, G. & Ocampo-Pérez, R. Pharmaceuticals as emerging contaminants and their removal from water. A review. PubMed

Kim, K. Y., Ekpe, O. D., Lee, H. J. & Oh, J. E. Perfluoroalkyl substances and pharmaceuticals removal in full-scale drinking water treatment plants. PubMed

Wilkinson, J. L. et al. Pharmaceutical pollution of the world’s rivers. PubMed PMC

Pharmaceutical Residues in Freshwater, OECD. 10.1787/c936f42d-en (2019).

González-González, R. B. et al. Persistence, environmental hazards, and mitigation of pharmaceutically active residual contaminants from water matrices. PubMed

Ortúzar, M., Esterhuizen, M., Olicón-Hernández, D. R., González-López, J. & Aranda, E. Pharmaceutical pollution in aquatic environments: A concise review of environmental impacts and bioremediation systems. PubMed PMC

Hunter, N. S., Anderson, K. C. & Cox, A. Pimavanserin, drugs of today. PubMed

Yunusa, I., El Helou, M. L. & Alsahali, S. Pimavanserin: A novel antipsychotic with potentials to address an unmet need of older adults with dementia-related psychosis. PubMed PMC

Kurhan, F. & Akın, M. A new hope in alzheimer’s disease psychosis: Pimavanserin, curr. PubMed

Hemine, K., Skwierawska, A., Kernstein, A. & Kozłowska-Tylingo, K. Cyclodextrin polymers as efficient adsorbents for removing toxic non-biodegradable Pimavanserin from pharmaceutical wastewaters. PubMed

Su, D. et al. Projections for prevalence of parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of global burden of disease study 2021. PubMed PMC

Pimavanserin Market Size. (n.d.). Share & Trends Analysis (2033). https://www.marketresearchintellect.com/product/global-pimavanserin-market/ (accessed 13 July 2025).

Eniola, J. O., Kumar, R., Barakat, M. A. & Rashid, J. A review on conventional and advanced hybrid technologies for pharmaceutical wastewater treatment.

Kanakaraju, D., Glass, B. D. & Oelgemöller, M. Advanced oxidation process-mediated removal of pharmaceuticals from water: A review. PubMed

Gopalakrishnan, G., Jeyakumar, R. B. & Somanathan, A. Challenges and emerging trends in advanced oxidation technologies and integration of advanced oxidation processes with biological processes for wastewater treatment.

Kujawska, A., Kiełkowska, U., Atisha, A., Yanful, E. & Kujawski, W. Comparative analysis of separation methods used for the elimination of pharmaceuticals and personal care products (PPCPs) from water—A critical review.

Taoufik, N., Boumya, W., Achak, M., Sillanpää, M. & Barka, N. Comparative overview of advanced oxidation processes and biological approaches for the removal pharmaceuticals. PubMed

Nasrollahi, N., Vatanpour, V. & Khataee, A. Removal of antibiotics from wastewaters by membrane technology: Limitations, successes, and future improvements. PubMed

Ferreira, I. A., Carreira, T. G., Diório, A., Bergamasco, R. & Vieira, M. F. Occurrence and removal of pharmaceuticals from water using modified zeolites: a review, desalin.

Mansouri, F., Chouchene, K., Roche, N. & Ksibi, M. Removal of pharmaceuticals from water by adsorption and advanced oxidation processes: state of the Art and trends.

Al-sareji, O. J. et al. Removal of emerging pollutants from water using enzyme-immobilized activated carbon from coconut shell.

Sophia, C. & Lima, A. E. C. Removal of emerging contaminants from the environment by adsorption. PubMed

Karimi-Maleh, H. et al. Recent advances in using of chitosan-based adsorbents for removal of pharmaceutical contaminants: A review.

Quesada, H. B. et al. Surface water pollution by pharmaceuticals and an alternative of removal by low-cost adsorbents: A review. PubMed

Zhai, M. et al. Simultaneous removal of pharmaceuticals and heavy metals from aqueous phase via adsorptive strategy: A critical review. PubMed

Alfonso-Muniozguren, P., Serna-Galvis, E. A., Bussemaker, M., Torres-Palma, R. A. & Lee, J. A review on pharmaceuticals removal from waters by single and combined biological, membrane filtration and ultrasound systems. PubMed PMC

Qalyoubi, L., Al-Othman, A. & Al-Asheh, S. Recent progress and challenges of adsorptive membranes for the removal of pollutants from wastewater. Part II: environmental applications, case stud.

Qalyoubi, L., Al-Othman, A. & Al-Asheh, S. Recent progress and challenges on adsorptive membranes for the removal of pollutants from wastewater. Part I: fundamentals and classification of membranes, case stud.

Chong, W. C., Choo, Y. L., Koo, C. H., Pang, Y. L. & Lai, S. O. Adsorptive membranes for heavy metal removal—A mini review. 020005. 10.1063/1.5126540 (2019).

Vo, T. S., Hossain, M. M., Jeong, H. M. & Kim, K. Heavy metal removal applications using adsorptive membranes. PubMed PMC

Cui, Z., Drioli, E. & Lee, Y. M. Recent progress in fluoropolymers for membranes.

Zou, D. & Lee, Y. M. Design strategy of poly(vinylidene fluoride) membranes for water treatment.

Saxena, P. & Shukla, P. A comprehensive review on fundamental properties and applications of poly(vinylidene fluoride) (PVDF).

Mohammadpourfazeli, S. et al. Future prospects and recent developments of polyvinylidene fluoride (PVDF) piezoelectric polymer; fabrication methods, structure, and electro-mechanical properties. PubMed PMC

Liu, F., Hashim, N. A., Liu, Y., Abed, M. R. M. & Li, K. Progress in the production and modification of PVDF membranes.

Kang, G. & Cao, Y. Application and modification of poly(vinylidene fluoride) (PVDF) membranes—A review.

Ahmed, M. M. et al. Revisiting the polyvinylidene fluoride heterogeneous alkaline reaction mechanism in propan-2-ol: an additional hydrogenation step.

Ahmed, M. M., Nowacka, D., Skwierawska, A. M. & Řezanka, M. Cyclodextrins functionalized polyvinylidene fluoride membranes: strategies and diverse applications.

Chen, C. et al. A high absorbent PVDF composite membrane based on β-cyclodextrin and ZIF-8 for rapid removing of heavy metal ions.

Kong, F. et al. Rejection of pharmaceuticals by graphene oxide membranes: role of crosslinker and rejection mechanism.

Ndlovu, L. N. et al. Beta cyclodextrin modified polyvinylidene fluoride adsorptive mixed matrix membranes for removal of congo red.

Wacławek, S. et al. Cyclodextrin-based strategies for removal of persistent organic pollutants. PubMed

Řezanka, M. Monosubstituted cyclodextrins as precursors for further use.

Iv Slavkova, M., Momekova, D. B., Kostova, B. D., Tz Momekov, G. & Petrov, P. D. Novel dextran/β-cyclodextrin and dextran macroporous cryogels for topical delivery of Curcumin in the treatment of cutaneous T-cell lymphoma (2017).

Ho, Y. & McKay, G. Pseudo-second order model for sorption processes.

Revellame, E. D., Fortela, D. L., Sharp, W., Hernandez, R. & Zappi, M. E. Adsorption kinetic modeling using pseudo-first order and pseudo-second order rate laws: A review.

Belhachemi, M. & Addoun, F. Comparative adsorption isotherms and modeling of methylene blue onto activated carbons.

Foo, K. Y. & Hameed, B. H. Insights into the modeling of adsorption isotherm systems.

Cao, Y. et al. Synthesis and antimicrobial applications of the inclusion complexes of β-cyclodextrin copolymers with potassium sorbate.

Jialanella, G. L. Advances in bonding plastics. In

Omar, H. A., Yusoff, N. I. M., Mubaraki, M. & Ceylan, H. Effects of moisture damage on asphalt mixtures.

Metcalf & Eddy

Fagundez, J. L. S., Netto, M. S., Dotto, G. L. & Salau, N. P. G. A new method of developing ANN-isotherm hybrid models for the determination of thermodynamic parameters in the adsorption of ions Ag+, Co2 + and Cu2 + onto zeolites ZSM-5, HY, and 4A.

Callies, O., Hernández, A. & Daranas Application of isothermal titration calorimetry as a tool to study natural product interactions. PubMed

Zamel, D. & Khan, A. U. New trends in nanofibers functionalization and recent applications in wastewater treatment.

El-Aswar, E. I., Ramadan, H., Elkik, H. & Taha, A. G. A comprehensive review on preparation, functionalization and recent applications of nanofiber membranes in wastewater treatment. PubMed

Okasha, A. T. et al. Progress of synthetic cyclodextrins-based materials as effective adsorbents of the common water pollutants: comprehensive review.