Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [LRRK2]
topical
2
- Terms
-
dardarin
PARK8
-
Dardarin Protein
LRRK2 Protein
PARK8 Protein
Persistent link
https://www.medvik.cz/link/D000071158
Definition
A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).
- DUI
- D000071158 MeSH Browser
- CUI
- M000613241
- Previous indexing
- Protein-Serine-Threonine Kinases (2005-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 2
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 1
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D08.811.913.696.620.682.700.108
Autophagy-Related Protein-1 Homolog
D08.811.913.696.620.682.700.150
Cyclic Nucleotide-Regulated Protein Kinases
D08.811.913.696.620.682.700.275
Doublecortin-Like Kinases
D08.811.913.696.620.682.700.288
Dyrk Kinases
D08.811.913.696.620.682.700.429
Glycogen Synthase Kinases
D08.811.913.696.620.682.700.616
Polo-like Kinases
D08.811.913.696.620.682.700.745
3-Phosphoinositide-Dependent Protein Kinases
D08.811.913.696.620.682.700.750
Protein Kinase D2
D08.811.913.696.620.682.700.783
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
D08.811.913.696.620.682.700.795
Receptor, Transforming Growth Factor-beta Type II
D08.811.913.696.620.682.700.897
Serine-Threonine Kinase 3
D08.811.913.696.620.682.700.965
Vacuolar Sorting Protein VPS15
D08.811.913.696.620.682.700.982
WNK Lysine-Deficient Protein Kinase 1
D12.776.476.563.108
Autophagy-Related Protein-1 Homolog
D12.776.476.563.150
Cyclic Nucleotide-Regulated Protein Kinases
D12.776.476.563.275
Doublecortin-Like Kinases
D12.776.476.563.288
Dyrk Kinases
D12.776.476.563.429
Glycogen Synthase Kinases
D12.776.476.563.616
Polo-like Kinases
D12.776.476.563.745
3-Phosphoinositide-Dependent Protein Kinases
D12.776.476.563.750
Protein Kinase D2
D12.776.476.563.783
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
D12.776.476.563.795
Receptor, Transforming Growth Factor-beta Type II
D12.776.476.563.897
Serine-Threonine Kinase 3
D12.776.476.563.965
Vacuolar Sorting Protein VPS15
D12.776.476.563.982
WNK Lysine-Deficient Protein Kinase 1
D12.776.705
Parkinson Disease Associated Proteins
D12.776.705.625
High-Temperature Requirement A Serine Peptidase 2