Werner Syndrome Helicase [helikáza Wernerova syndromu]

topical
2
Terms

gen RECQL2
protein RecQ3
recQ-like helikáza Wernerova syndromu
RECQ3 gen
Wernerova helikáza
WRN gen

 

RECQ3 Protein
RECQL2 Protein
Werner Syndrome ATP-Dependent Helicase
Werner Syndrome RecQ-Like Helicase

Persistent link   https://www.medvik.cz/link/D000071657
Definition

A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.

DUI
D000071657 MeSH Browser
CUI
M000615275
Previous indexing
Exodeoxyribonucleases (1996-2016); RecQ Helicases (2006-2016)
History note
2017
Public note
2017

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 1
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 1
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.040 Acid Anhydride Hydrolases 6
D08.811.277.040.025 Adenosine Triphosphatases 429
D08.811.277.040.025.159 DNA Helicases 63
D08.811.277.040.025.159.249 RecQ Helicases 17
D08.811.277.040.025.159.249.500 Werner Syndrome Helicase 2
D08.811.277.352 Esterases 207
D08.811.277.352.335 Deoxyribonucleases 59
D08.811.277.352.335.375 Exodeoxyribonucleases 17
D08.811.277.352.335.375.750 Exodeoxyribonuclease V 2
D08.811.277.352.335.375.813 MRE11 Homologue Protein 6
D08.811.277.352.335.375.875 Werner Syndrome Helicase 2
D08.811.277.352.365 Exonucleases 5
D08.811.277.352.365.290 Exodeoxyribonucleases 17
D08.811.277.352.365.290.250 MRE11 Homologue Protein 6
D08.811.277.352.365.290.500 Werner Syndrome Helicase 2
D08.811.399 Isomerases 18
D08.811.399.340 DNA Helicases 63
D08.811.399.340.249 RecQ Helicases 17
D08.811.399.340.249.500 Werner Syndrome Helicase 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.157 Carrier Proteins 546
D12.776.157.687 Poly-ADP-Ribose Binding Proteins 5
D12.776.157.687.063 Apoptosis Inducing Factor 10
D12.776.157.687.125 Ataxia Telangiectasia Mutated Proteins 89
D12.776.157.687.157 CCCTC-Binding Factor 2
D12.776.157.687.173 Centromere Protein A 2
D12.776.157.687.188 Centromere Protein B
D12.776.157.687.250 Cyclin-Dependent Kinase Inhibitor p21 74
D12.776.157.687.313 DNA (Cytosine-5-)-Methyltransferase 1 7
D12.776.157.687.375 DNA Topoisomerases, Type I 24
D12.776.157.687.438 DNA-Activated Protein Kinase 14
D12.776.157.687.450 Heat Shock Transcription Factors 1
D12.776.157.687.462 Heterogeneous Nuclear Ribonucleoprotein A1
D12.776.157.687.485 Histones 368
D12.776.157.687.493 Ku Autoantigen 5
D12.776.157.687.495 MRE11 Homologue Protein 6
D12.776.157.687.496 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.157.687.497 NF-kappa B p52 Subunit 2
D12.776.157.687.499 Nicotinamide-Nucleotide Adenylyltransferase 3
D12.776.157.687.575 Nitric Oxide Synthase Type II 75
D12.776.157.687.613 Telomerase 189
D12.776.157.687.650 Tumor Suppressor Protein p53 755
D12.776.157.687.750 Werner Syndrome Helicase 2
D12.776.157.687.813 X-ray Repair Cross Complementing Protein 1 9
D12.776.157.687.875 Xeroderma Pigmentosum Group A Protein 2
D12.776.660 Nuclear Proteins 452
D12.776.660.720 Poly-ADP-Ribose Binding Proteins 5
D12.776.660.720.063 Apoptosis Inducing Factor 10
D12.776.660.720.125 Ataxia Telangiectasia Mutated Proteins 89
D12.776.660.720.157 CCCTC-Binding Factor 2
D12.776.660.720.173 Centromere Protein A 2
D12.776.660.720.188 Centromere Protein B
D12.776.660.720.250 Cyclin-Dependent Kinase Inhibitor p21 74
D12.776.660.720.313 DNA (Cytosine-5-)-Methyltransferase 1 7
D12.776.660.720.375 DNA Topoisomerases, Type I 24
D12.776.660.720.438 DNA-Activated Protein Kinase 14
D12.776.660.720.462 Heat Shock Transcription Factors 1
D12.776.660.720.485 Histones 368
D12.776.660.720.493 Ku Autoantigen 5
D12.776.660.720.495 MRE11 Homologue Protein 6
D12.776.660.720.496 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.660.720.497 NF-kappa B p52 Subunit 2
D12.776.660.720.499 Nicotinamide-Nucleotide Adenylyltransferase 3
D12.776.660.720.575 Nitric Oxide Synthase Type II 75
D12.776.660.720.613 Telomerase 189
D12.776.660.720.650 Tumor Suppressor Protein p53 755
D12.776.660.720.750 Werner Syndrome Helicase 2
D12.776.660.720.813 X-ray Repair Cross Complementing Protein 1 9
D12.776.660.720.875 Xeroderma Pigmentosum Group A Protein 2

WRN protein, Xenopus Chemical MeSH Browser

WRN protein, human Chemical MeSH Browser

WRN protein, rat Chemical MeSH Browser

Wrn protein, mouse Chemical MeSH Browser

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