protein CENP-A [Centromere Protein A]

tematický
2
Termíny

centromerový protein A
centromérový protein A

 

CENP-A Protein
CENPA Protein
Centromere Autoantigens 17K
Centromere Protein 17K

Perzistentní odkaz   https://www.medvik.cz/link/D000076247
Definice

A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.

DUI
D000076247 MeSH Prohlížeč
CUI
M0147022
Historická pozn.
2018 (1987)
Veřejná pozn.
2018; CENTROMERE PROTEIN A was indexed under AUTOANTIGENS 1987-2017 and CHROMOSOMAL PROTEINS, NON-HISTONE 1990-2017; and under NUCLEOPROTEINS 1987-1989

Povolená podhesla

AG
agonisté 0
AN
analýza 0
AI
antagonisté a inhibitory 0
AD
aplikace a dávkování 0
BI
biosyntéza 0
CS
chemická syntéza 0
CH
chemie 1
HI
dějiny 0
EC
ekonomika 0
PK
farmakokinetika 0
PD
farmakologie 0
PH
fyziologie 0
GE
genetika 1
IM
imunologie 0
IP
izolace a purifikace 0
CL
klasifikace 0
BL
krev 0
ME
metabolismus 0
UR
moč 0
CF
mozkomíšní mok 0
DF
nedostatek 0
ST
normy 0
PO
otrava 0
AE
škodlivé účinky 0
TU
terapeutické užití 0
TO
toxicita 0
DE
účinky léků 0
RE
účinky záření 0
UL
ultrastruktura 0
SD
zásobování a distribuce 0

D Chemikálie a léčiva
D12 aminokyseliny, peptidy a proteiny 16
D12.776 proteiny 2 575
D12.776.157 transportní proteiny 546
D12.776.157.687 proteiny vázající poly-ADP-ribosu 5
D12.776.157.687.063 faktor vyvolávající apoptózu 10
D12.776.157.687.125 ATM protein 89
D12.776.157.687.157 CCCTC-vazebný faktor 2
D12.776.157.687.173 protein CENP-A 2
D12.776.157.687.188 protein CENP-B
D12.776.157.687.250 inhibitor p21 cyklin-dependentní kinasy 74
D12.776.157.687.313 DNA-(cytosin-5)-methyltransferasa 1 7
D12.776.157.687.375 DNA-topoisomerasy I 24
D12.776.157.687.438 proteinkinasa aktivovaná DNA 14
D12.776.157.687.450 transkripční faktory tepelného šoku 1
D12.776.157.687.462 heterogenní jaderný ribonukleoprotein A1
D12.776.157.687.485 histony 368
D12.776.157.687.493 antigen Ku 5
D12.776.157.687.495 homologní protein MRE11 6
D12.776.157.687.496 protein MARCKS
D12.776.157.687.497 NF-kappa B - podjednotka p52 2
D12.776.157.687.499 nikotinamidnukleotidadenylyltransferasa 3
D12.776.157.687.575 synthasa oxidu dusnatého, typ II 75
D12.776.157.687.613 telomerasa 189
D12.776.157.687.650 nádorový supresorový protein p53 755
D12.776.157.687.750 helikáza Wernerova syndromu 2
D12.776.157.687.813 protein XRCC1 9
D12.776.157.687.875 xeroderma pigmentosum - protein skupiny A 2
D12.776.260 DNA vazebné proteiny 556
D12.776.260.060 adenovirové proteiny E2 1
D12.776.260.103 transkripční faktory bHLH 61
D12.776.260.108 transkripční faktory bZIP 18
D12.776.260.114 faktor 1 butyrátové odpovědi
D12.776.260.120 CCCTC-vazebný faktor 2
D12.776.260.123 protein CENP-A 2
D12.776.260.125 protein CENP-B
D12.776.260.158 transkripční faktory časné růstové odpovědi 1
D12.776.260.197 elongin
D12.776.260.235 specifické DNA vazebné faktory erythroidních buněk 1
D12.776.260.246 protein faktoru stimulujícího zvrat růstu
D12.776.260.254 faktory vázající G-box
D12.776.260.257 transkripční faktory GATA 2
D12.776.260.260 transkripční faktory tepelného šoku 1
D12.776.260.262 hepatocytární jaderné faktory 5
D12.776.260.268 heterogenní jaderný ribonukleoprotein K
D12.776.260.312 proteiny HMGA 1
D12.776.260.356 proteiny HMGB 4
D12.776.260.400 homeodoménové proteiny 122
D12.776.260.420 proteiny I-kappa B 5
D12.776.260.457 protein RBP-Jkappa
D12.776.260.495 integrační hostitelské faktory
D12.776.260.504 interferonové regulační faktory 11
D12.776.260.513 transkripční faktor ISGF3
D12.776.260.522 transkripční faktory Krüppel-like 26
D12.776.260.525 antigen Ku 5
D12.776.260.527 regulační protein responzivní pro leucin
D12.776.260.529 proteiny s homeodoménou LIM 5
D12.776.260.531 jaterní receptor X 5
D12.776.260.532 vazebné proteiny DNA v oblastech připojení k matrix 9
D12.776.260.534 protein MDS1 and EVI1 complex locus 2
D12.776.260.536 protein 2 vázající methyl-CpG 12
D12.776.260.538 protein MCM1 1
D12.776.260.539 homologní protein MRE11 6
D12.776.260.540 MutL proteiny
D12.776.260.556 proteiny MutS
D12.776.260.560 protoonkogenní protein MLL 39
D12.776.260.600 NF-kappa B 215
D12.776.260.605 transkripční faktory NFI 6
D12.776.260.615 jaderné respirační faktory
D12.776.260.623 nukleobindiny 3
D12.776.260.630 onkogenní protein p55(v-myc) 1
D12.776.260.640 komplex rozpoznávající replikační počátek 1
D12.776.260.643 sirotčí receptory 2
D12.776.260.645 transkripční faktory paired box 21
D12.776.260.650 protein PIN4
D12.776.260.655 faktory domény POU 4
D12.776.260.660 protoonkogenní proteiny c-bcl-6 3
D12.776.260.665 protoonkogenní proteiny c-ets 19
D12.776.260.675 protoonkogenní proteiny c-myb 30
D12.776.260.682 protoonkogenní proteiny c-rel 2
D12.776.260.690 protoonkogenní proteiny c-sis 3
D12.776.260.693 sestřihový faktor PSF
D12.776.260.695 rekombinasa Rad51 42
D12.776.260.696 DNA opravný a rekombinační protein Rad52 9
D12.776.260.700 replikační protein A 12
D12.776.260.702 replikační protein C 3
D12.776.260.703 represorové proteiny 189
D12.776.260.704 retinoblastomový protein 52
D12.776.260.713 proteiny Smad 14
D12.776.260.716 gen SMARCB1 15
D12.776.260.719 transkripční faktory SOX 1
D12.776.260.725 proteiny T-boxu 14
D12.776.260.730 transkripční faktory TCF 3
D12.776.260.733 transkripční faktory TEA domény 3
D12.776.260.735 proteiny vázající telomery 24
D12.776.260.750 toll-like receptor 9 16
D12.776.260.755 trans-aktivátory 110
D12.776.260.760 transkripční faktor AP-2 1
D12.776.260.768 transkripční faktor MTF-1
D12.776.260.775 transkripční faktory hlavní 1
D12.776.260.790 tristetraprolin 2
D12.776.260.805 53BP1 16
D12.776.260.820 nádorový supresorový protein p53 755
D12.776.260.885 protein p73 6
D12.776.260.950 winged-helix transkripční faktory
D12.776.260.963 protein XRCC1 9
D12.776.260.975 xeroderma pigmentosum - protein skupiny A 2
D12.776.660 jaderné proteiny 452
D12.776.660.235 chromozomální proteiny, nehistonové 93
D12.776.660.235.025 proteiny obsahující bromodoménu 3
D12.776.660.235.050 CCCTC-vazebný faktor 2
D12.776.660.235.100 protein CENP-A 2
D12.776.660.235.199 protein CENP-B
D12.776.660.235.300 homolog proteinu s chromoboxem 5
D12.776.660.235.350 koheziny
D12.776.660.235.400 proteiny s vysokou pohyblivostí 20
D12.776.660.235.500 MCM proteiny 4
D12.776.660.235.550 protein 2 vázající methyl-CpG 12
D12.776.660.235.600 polycomb proteiny 7
D12.776.660.235.650 gen SMARCB1 15
D12.776.660.235.675 protein SMC1
D12.776.660.235.700 proteiny vázající telomery 24
D12.776.660.235.850 53BP1 16
D12.776.660.720 proteiny vázající poly-ADP-ribosu 5
D12.776.660.720.063 faktor vyvolávající apoptózu 10
D12.776.660.720.125 ATM protein 89
D12.776.660.720.157 CCCTC-vazebný faktor 2
D12.776.660.720.173 protein CENP-A 2
D12.776.660.720.188 protein CENP-B
D12.776.660.720.250 inhibitor p21 cyklin-dependentní kinasy 74
D12.776.660.720.313 DNA-(cytosin-5)-methyltransferasa 1 7
D12.776.660.720.375 DNA-topoisomerasy I 24
D12.776.660.720.438 proteinkinasa aktivovaná DNA 14
D12.776.660.720.462 transkripční faktory tepelného šoku 1
D12.776.660.720.485 histony 368
D12.776.660.720.493 antigen Ku 5
D12.776.660.720.495 homologní protein MRE11 6
D12.776.660.720.496 protein MARCKS
D12.776.660.720.497 NF-kappa B - podjednotka p52 2
D12.776.660.720.499 nikotinamidnukleotidadenylyltransferasa 3
D12.776.660.720.575 synthasa oxidu dusnatého, typ II 75
D12.776.660.720.613 telomerasa 189
D12.776.660.720.650 nádorový supresorový protein p53 755
D12.776.660.720.750 helikáza Wernerova syndromu 2
D12.776.660.720.813 protein XRCC1 9
D12.776.660.720.875 xeroderma pigmentosum - protein skupiny A 2
D12.776.664 nukleoproteiny 91
D12.776.664.235 chromozomální proteiny, nehistonové 93
D12.776.664.235.025 proteiny obsahující bromodoménu 3
D12.776.664.235.050 CCCTC-vazebný faktor 2
D12.776.664.235.100 protein CENP-A 2
D12.776.664.235.199 protein CENP-B
D12.776.664.235.300 homolog proteinu s chromoboxem 5
D12.776.664.235.350 koheziny
D12.776.664.235.400 proteiny s vysokou pohyblivostí 20
D12.776.664.235.700 protein 2 vázající methyl-CpG 12
D12.776.664.235.750 MCM proteiny 4
D12.776.664.235.800 polycomb proteiny 7
D12.776.664.235.900 gen SMARCB1 15
D12.776.664.235.925 protein SMC1
D12.776.664.235.950 53BP1 16
D23 biologické faktory 143
D23.050 antigeny 1 131
D23.050.422 autoantigeny 118
D23.050.422.031 protein CENP-A 2
D23.050.422.061 protein CENP-B
D23.050.422.093 kolagen typu XVII
D23.050.422.124 desmoglein 1 1
D23.050.422.249 desmoglein 3 4
D23.050.422.500 antigenní komplex Heymannovy nefritidy
D23.050.422.625 glykoprotein v myelinu oligodendrocytů 14
D23.050.422.750 jádro snRNP - proteiny 1
D23.050.422.875 antigen SS-B

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