Cytokine TWEAK [cytokin TWEAK]
- Terms
-
slabý induktor apoptózy skupiny tumor nekrotizujícího faktoru
slabý induktor apoptózy TNF
TNF příbuzný slabý induktor apoptózy
TWEAK
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Apo3 Ligand
TNF-Related Weak Inducer of Apoptosis
Tumor Necrosis Factor Ligand Superfamily Member 12
TWEAK Cytokine
A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
- DUI
- D000074049 MeSH Browser
- CUI
- M000625319
- Previous indexing
- Tumor Necrosis Factors (2006-2017)
- History note
- 2018
- Public note
- 2018
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood 2
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
TNFSF12 protein, human Chemical MeSH Browser
TNFSF12 protein, zebrafish Chemical MeSH Browser
Tnfsf12 protein, mouse Chemical MeSH Browser
Tnfsf12 protein, rat Chemical MeSH Browser