Spastin [spastin]

topical
Terms

protein spastin

 

Spastic Paraplegia 4 Protein

Persistent link   https://www.medvik.cz/link/D000074181
Definition

An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.

DUI
D000074181 MeSH Browser
CUI
M000625779
Previous indexing
Adenosine Triphosphatases (1999-2017)
History note
2018
Public note
2018

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 0
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.040 Acid Anhydride Hydrolases 6
D08.811.277.040.013 AAA Proteins
D08.811.277.040.013.500 ATPases Associated with Diverse Cellular Activities 8
D08.811.277.040.013.500.032 ATP-Dependent Proteases 7
D08.811.277.040.013.500.063 Dyneins 12
D08.811.277.040.013.500.250 Katanin 2
D08.811.277.040.013.500.375 N-Ethylmaleimide-Sensitive Proteins
D08.811.277.040.013.500.438 Replication Protein C 3
D08.811.277.040.013.500.500 Spastin
D08.811.277.040.013.500.750 Valosin Containing Protein 2
D08.811.277.040.025 Adenosine Triphosphatases 429
D08.811.277.040.025.024 ATPases Associated with Diverse Cellular Activities 8
D08.811.277.040.025.024.032 ATP-Dependent Proteases 7
D08.811.277.040.025.024.063 Dyneins 12
D08.811.277.040.025.024.250 Katanin 2
D08.811.277.040.025.024.375 N-Ethylmaleimide-Sensitive Proteins
D08.811.277.040.025.024.438 Replication Protein C 3
D08.811.277.040.025.024.500 Spastin
D08.811.277.040.025.024.750 Valosin Containing Protein 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.157 Carrier Proteins 546
D12.776.157.025 AAA Proteins
D12.776.157.025.750 ATPases Associated with Diverse Cellular Activities 8
D12.776.157.025.750.032 ATP-Dependent Proteases 7
D12.776.157.025.750.063 Dyneins 12
D12.776.157.025.750.250 Katanin 2
D12.776.157.025.750.375 N-Ethylmaleimide-Sensitive Proteins
D12.776.157.025.750.438 Replication Protein C 3
D12.776.157.025.750.500 Spastin
D12.776.157.025.750.750 Valosin Containing Protein 2
D12.776.220 Cytoskeletal Proteins 97
D12.776.220.600 Microtubule Proteins 22
D12.776.220.600.450 Microtubule-Associated Proteins 101
D12.776.220.600.450.100 Autophagy-Related Protein 8 Family 2
D12.776.220.600.450.125 Doublecortin Domain Proteins
D12.776.220.600.450.150 Dynactin Complex 1
D12.776.220.600.450.200 Dynamins 4
D12.776.220.600.450.325 Katanin 2
D12.776.220.600.450.450 Kinesins 38
D12.776.220.600.450.458 KRIT1 Protein
D12.776.220.600.450.465 Spastin
D12.776.220.600.450.480 Stathmin 4
D12.776.220.600.450.495 Survivin 6
D12.776.220.600.450.510 tau Proteins 217
D12.776.631 Nerve Tissue Proteins 263
D12.776.631.560 Microtubule-Associated Proteins 101
D12.776.631.560.113 Doublecortin Protein 1
D12.776.631.560.225 Dynactin Complex 1
D12.776.631.560.338 Katanin 2
D12.776.631.560.450 Kinesins 38
D12.776.631.560.465 KRIT1 Protein
D12.776.631.560.480 Spastin
D12.776.631.560.510 tau Proteins 217

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