Nedd4 Ubiquitin Protein Ligases [ubikvitinligasy Nedd4]
- Terms
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proteiny Nedd4
ubikvitinligázy Nedd4
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Nedd4 Proteins
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
- DUI
- D000075702 MeSH Browser
- CUI
- M0453577
- RN
- EC 2.3.2.26
- History note
- 2018 (1996)
- Public note
- 2018; NEDD4 UBIQUITIN PROTEIN LIGASES was indexed under UBIQUITIN-PROTEIN LIGASES and ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT 2005-2017; under LIGASES 1996-2004; and under CALCIUM-BINDING PROTEINS 1996-2003
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