E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

DUI

D000075702 MeSH Browser

CUI

M0453577

History note

2018 (1996)

Public note

2018; NEDD4 UBIQUITIN PROTEIN LIGASES was indexed under UBIQUITIN-PROTEIN LIGASES and ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT 2005-2017; under LIGASES 1996-2004; and under CALCIUM-BINDING PROTEINS 1996-2003