WNK Lysine-Deficient Protein Kinase 1 [lysin-deficitní proteinkinasa WNK]

topical
Terms

lysin-deficitní proteinkináza WNK

Definition

A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

DUI
D000076204 MeSH Browser
CUI
M000632439
Previous indexing
Intracellular Signaling Peptides and Proteins (2005-2017); Minor Histocompatibility Antigens (2005-2017); Protein-Serine-Threonine Kinases (2005-2017)
History note
2018
Public note
2018

D Chemicals and Drugs
D08.811 Enzymes 1 547
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620.682 Protein Kinases 248
D08.811.913.696.620.682.700 Protein Serine-Threonine Kinases 271
D08.811.913.696.620.682.700.062 Activin Receptors 5
D08.811.913.696.620.682.700.074 AMP-Activated Protein Kinase Kinases 1
D08.811.913.696.620.682.700.085 AMP-Activated Protein Kinases 41
D08.811.913.696.620.682.700.097 Ataxia Telangiectasia Mutated Proteins 89
D08.811.913.696.620.682.700.103 Aurora Kinases 4
D08.811.913.696.620.682.700.108 Autophagy-Related Protein-1 Homolog
D08.811.913.696.620.682.700.109 Bone Morphogenetic Protein Receptors 3
D08.811.913.696.620.682.700.125 Calcium-Calmodulin-Dependent Protein Kinases 10
D08.811.913.696.620.682.700.140 Casein Kinases 1
D08.811.913.696.620.682.700.143 Checkpoint Kinase 1 19
D08.811.913.696.620.682.700.145 Checkpoint Kinase 2 49
D08.811.913.696.620.682.700.150 Cyclic Nucleotide-Regulated Protein Kinases
D08.811.913.696.620.682.700.250 DNA-Activated Protein Kinase 14
D08.811.913.696.620.682.700.275 Doublecortin-Like Kinases
D08.811.913.696.620.682.700.288 Dyrk Kinases
D08.811.913.696.620.682.700.300 eIF-2 Kinase 8
D08.811.913.696.620.682.700.364 G-Protein-Coupled Receptor Kinases 2
D08.811.913.696.620.682.700.397 Germinal Center Kinases 2
D08.811.913.696.620.682.700.429 Glycogen Synthase Kinases
D08.811.913.696.620.682.700.494 I-kappa B Kinase 9
D08.811.913.696.620.682.700.526 Interleukin-1 Receptor-Associated Kinases 3
D08.811.913.696.620.682.700.542 Lim Kinases 2
D08.811.913.696.620.682.700.559 MAP Kinase Kinase Kinases 48
D08.811.913.696.620.682.700.565 Mitogen-Activated Protein Kinase Kinases 40
D08.811.913.696.620.682.700.567 Mitogen-Activated Protein Kinases 100
D08.811.913.696.620.682.700.576 Myotonin-Protein Kinase 2
D08.811.913.696.620.682.700.579 NF-kappaB-Inducing Kinase 1
D08.811.913.696.620.682.700.581 NIMA-Related Kinases 4
D08.811.913.696.620.682.700.586 Oncogene Protein v-akt 5
D08.811.913.696.620.682.700.596 p21-Activated Kinases 9
D08.811.913.696.620.682.700.606 Phytochrome A 2
D08.811.913.696.620.682.700.616 Polo-like Kinases
D08.811.913.696.620.682.700.626 Positive Transcriptional Elongation Factor B 4
D08.811.913.696.620.682.700.646 Proline-Directed Protein Kinases 1
D08.811.913.696.620.682.700.725 Protein Kinase C 138
D08.811.913.696.620.682.700.745 3-Phosphoinositide-Dependent Protein Kinases
D08.811.913.696.620.682.700.750 Protein Kinase D2
D08.811.913.696.620.682.700.755 Proto-Oncogene Proteins c-akt 116
D08.811.913.696.620.682.700.759 Proto-Oncogene Proteins c-bcr 19
D08.811.913.696.620.682.700.776 Proto-Oncogene Proteins c-pim-1 1
D08.811.913.696.620.682.700.789 Receptor, Transforming Growth Factor-beta Type I 2
D08.811.913.696.620.682.700.814 rho-Associated Kinases 26
D08.811.913.696.620.682.700.862 Ribosomal Protein S6 Kinases 1
D08.811.913.696.620.682.700.897 Serine-Threonine Kinase 3
D08.811.913.696.620.682.700.931 TOR Serine-Threonine Kinases 193
D08.811.913.696.620.682.700.965 Vacuolar Sorting Protein VPS15
D08.811.913.696.620.682.700.982 WNK Lysine-Deficient Protein Kinase 1
D12.776 Proteins 2 575
D12.776.476.563.062 Activin Receptors 5
D12.776.476.563.085 AMP-Activated Protein Kinases 41
D12.776.476.563.103 Aurora Kinases 4
D12.776.476.563.140 Casein Kinases 1
D12.776.476.563.143 Checkpoint Kinase 1 19
D12.776.476.563.145 Checkpoint Kinase 2 49
D12.776.476.563.250 DNA-Activated Protein Kinase 14
D12.776.476.563.275 Doublecortin-Like Kinases
D12.776.476.563.288 Dyrk Kinases
D12.776.476.563.300 eIF-2 Kinase 8
D12.776.476.563.397 Germinal Center Kinases 2
D12.776.476.563.429 Glycogen Synthase Kinases
D12.776.476.563.494 I-kappa B Kinase 9
D12.776.476.563.542 Lim Kinases 2
D12.776.476.563.554 MAP Kinase Kinase Kinases 48
D12.776.476.563.567 Mitogen-Activated Protein Kinases 100
D12.776.476.563.576 Myotonin-Protein Kinase 2
D12.776.476.563.579 NF-kappaB-Inducing Kinase 1
D12.776.476.563.581 NIMA-Related Kinases 4
D12.776.476.563.586 Oncogene Protein v-akt 5
D12.776.476.563.596 p21-Activated Kinases 9
D12.776.476.563.606 Phytochrome A 2
D12.776.476.563.616 Polo-like Kinases
D12.776.476.563.725 Protein Kinase C 138
D12.776.476.563.750 Protein Kinase D2
D12.776.476.563.755 Proto-Oncogene Proteins c-akt 116
D12.776.476.563.759 Proto-Oncogene Proteins c-bcr 19
D12.776.476.563.776 Proto-Oncogene Proteins c-pim-1 1
D12.776.476.563.814 rho-Associated Kinases 26
D12.776.476.563.862 Ribosomal Protein S6 Kinases 1
D12.776.476.563.897 Serine-Threonine Kinase 3
D12.776.476.563.931 TOR Serine-Threonine Kinases 193
D23.050 Antigens 1 131
D23.050.301 Antigens, Surface 170
D23.050.301.500 Histocompatibility Antigens 105
D23.050.301.500.600.200 Antigens, CD19 52
D23.050.301.500.600.300 Cathepsin H 1
D23.050.301.500.600.350 Focal Adhesion Kinase 2 4
D23.050.301.500.600.400 H-Y Antigen 3
D23.050.301.500.600.700 Receptor, ErbB-2 584
D23.050.301.500.600.775 Receptors, Purinergic P2X5
D23.050.301.500.600.813 Reduced Folate Carrier Protein 1
D23.050.301.500.600.925 Thymidine Phosphorylase 24
D23.050.705 Isoantigens 438
D23.050.705.552 Histocompatibility Antigens 105
D23.050.705.552.600.200 Antigens, CD19 52
D23.050.705.552.600.300 Cathepsin H 1
D23.050.705.552.600.350 Focal Adhesion Kinase 2 4
D23.050.705.552.600.400 H-Y Antigen 3
D23.050.705.552.600.550 Receptor, ErbB-2 584
D23.050.705.552.600.625 Receptors, Purinergic P2X5
D23.050.705.552.600.663 Reduced Folate Carrier Protein 1
D23.050.705.552.600.850 Thymidine Phosphorylase 24