inhibitory a modulátory gama-sekretázy [Gamma Secretase Inhibitors and Modulators]

tematický
Termíny

inhibitory a modulátory GS
inhibitory gama-sekretázy
inhibitory GS
modulátory gama-sekretázy

 

Gamma Secretase Inhibitors
Gamma Secretase Modulators
GS Inhibitors
GS Inhibitors and Modulators
GS Modulators

Perzistentní odkaz   https://www.medvik.cz/link/D000091062
Definice

Látky, které potlačují gama-sekretázu inhibicí nebo modulací její aktivity. Mezi cílené enzymatické aktivity patří její účast na akumulaci toxických amyloidních beta-proteinů (např. Aβ42) u Alzheimerovy choroby a aktivace signálních drah zprostředkovaných receptorem Notch u některých typů rakoviny.

Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.

DUI
D000091062 MeSH Prohlížeč
CUI
M000747845
Předchozí užití
Amyloid Precursor Protein Secretases (1995-2021)
Historická pozn.
2022
Veřejná pozn.
2022

D Chemikálie a léčiva
D09 sacharidy 723
D10 lipidy 2 526
D27.505.519.389 inhibitory enzymů 880
D27.505.519.389.092 inhibitory adenosindeaminasy 6
D27.505.519.389.108 inhibitory adenylylcyklasy 14
D27.505.519.389.174 inhibitory kalcineurinu 122
D27.505.519.389.200 inhibitory karboanhydras 60
D27.505.519.389.275 cholinesterasové inhibitory 967
D27.505.519.389.310 inhibitory cyklooxygenasy 454
D27.505.519.389.335 inhibitory cytochromu P450 93
D27.505.519.389.350 antagonisté kyseliny listové 67
D27.505.519.389.360 inhibitory histondeacetylas 110
D27.505.519.389.370 statiny 1 841
D27.505.519.389.375 inhibitory integrasy 4
D27.505.519.389.400 inhibitory beta-laktamasy 75
D27.505.519.389.480 inhibitory lipoxygenas 51
D27.505.519.389.616 inhibitory MAO 155
D27.505.519.389.735 inhibitory fosfodiesteras 405
D27.505.519.389.737 inhibitory fosfolipasy A2 9
D27.505.519.389.739 PARP inhibitory 189
D27.505.519.389.740 inhibitory prolylhydroxylas 3
D27.505.519.389.745 inhibitory proteas 273
D27.505.519.389.755 inhibitory proteinkinas 1 376
D27.505.519.389.760 inhibitory syntézy proteinů 37
D27.505.519.389.848 inhibitory protonové pumpy 493
D27.505.519.389.870 inhibitory syntézy steroidů 1
D27.505.519.389.892 inhibitory topoisomeras 7
D27.505.519.389.936 rozpřahující látky 24