PINK1 kinasa [PTEN-Induced Putative Kinase]

tematický
Termíny

kinasa PINK1
PINK1 kináza
PTEN indukovaná kinasa 1
PTEN indukovaná kináza 1

 

PINK1 Kinase

Perzistentní odkaz   https://www.medvik.cz/link/D000099202
Definice

A serine-threonine-protein kinase which senses damaged MITOCHONDRIA and protects against mitochondrial dysfunction caused by PHYSIOLOGICAL STRESS. It phosphorylates proteins on the OUTER MITOCHONDRIAL MEMBRANE to coordinate quality control mechanisms that remove and replace dysfunctional mitochondrial components. Mutations in the PINK1 gene, which encodes PTEN-induced putative kinase, are associated with PARKINSON DISEASE.

DUI
D000099202 MeSH Prohlížeč
CUI
M000768947
Historická pozn.
2026 (2001)
Veřejná pozn.
2026; PTEN-INDUCED PUTATIVE KINASE was indexed under PROTEIN KINASES 2001-2026

Povolená podhesla

AN
analýza
AI
antagonisté a inhibitory
AD
aplikace a dávkování
BI
biosyntéza
CS
chemická syntéza
CH
chemie
HI
dějiny
EC
ekonomika
PK
farmakokinetika
PD
farmakologie
PH
fyziologie
GE
genetika
IM
imunologie
IP
izolace a purifikace
CL
klasifikace
BL
krev
ME
metabolismus
UR
moč
CF
mozkomíšní mok
DF
nedostatek
ST
normy
PO
otrava
AE
škodlivé účinky
TU
terapeutické užití
TO
toxicita
DE
účinky léků
RE
účinky záření
UL
ultrastruktura
SD
zásobování a distribuce

D Chemikálie a léčiva
D08 enzymy a koenzymy 7
D08.811 enzymy 1 557
D08.811.913 transferasy 72
D08.811.913.696 fosfotransferasy 69
D08.811.913.696.620 fosfotransferasy s alkoholovou skupinou jako akceptorem 32
D08.811.913.696.620.682 proteinkinasy 249
D08.811.913.696.620.682.700 protein-serin-threoninkinasy 274
D08.811.913.696.620.682.700.062 aktivinové receptory 6
D08.811.913.696.620.682.700.074 kinasy AMP aktivovaných proteinkinas 1
D08.811.913.696.620.682.700.085 proteinkinasy aktivované AMP 44
D08.811.913.696.620.682.700.097 ATM protein 92
D08.811.913.696.620.682.700.103 kinasy Aurora 4
D08.811.913.696.620.682.700.108 homolog Atg1 1
D08.811.913.696.620.682.700.109 receptory kostního morfogenetického proteinu 3
D08.811.913.696.620.682.700.125 proteinkinasy závislé na vápníku a kalmodulinu 10
D08.811.913.696.620.682.700.140 kaseinkinasy 1
D08.811.913.696.620.682.700.143 checkpoint kinasa 1 20
D08.811.913.696.620.682.700.145 checkpoint kinasa 2 51
D08.811.913.696.620.682.700.150 cyklickými nukleotidy regulované proteinkinasy
D08.811.913.696.620.682.700.250 proteinkinasa aktivovaná DNA 15
D08.811.913.696.620.682.700.275 kinasy podobné doublecortinu
D08.811.913.696.620.682.700.288 kinasy Dyrk
D08.811.913.696.620.682.700.294 kinasy Hippo
D08.811.913.696.620.682.700.300 kinasa eIF-2 8
D08.811.913.696.620.682.700.364 kinasy receptorů spřažených s G-proteiny 2
D08.811.913.696.620.682.700.397 kinázy zárodečného centra 2
D08.811.913.696.620.682.700.429 kinasy glykogensynthasy
D08.811.913.696.620.682.700.494 kinasa I-kappa B 9
D08.811.913.696.620.682.700.526 kinázy asociované s receptory interleukinu-1 3
D08.811.913.696.620.682.700.534 LRRK2 4
D08.811.913.696.620.682.700.542 Lim-kinasy 2
D08.811.913.696.620.682.700.550 proteinkinasa teplotního šoku 2
D08.811.913.696.620.682.700.559 MAP kinasy kinas (kinas) 48
D08.811.913.696.620.682.700.565 mitogenem aktivované proteinkinasy kinas 42
D08.811.913.696.620.682.700.567 mitogenem aktivované proteinkinasy 101
D08.811.913.696.620.682.700.576 DM-kinasa 2
D08.811.913.696.620.682.700.579 kinasa indukující NF-kappaB 1
D08.811.913.696.620.682.700.581 kinasy NEK 4
D08.811.913.696.620.682.700.586 onkogenní protein v-akt 5
D08.811.913.696.620.682.700.596 p21 aktivované kinasy 9
D08.811.913.696.620.682.700.606 fytochrom A 2
D08.811.913.696.620.682.700.616 polo-like kinasy
D08.811.913.696.620.682.700.626 pozitivní transkripční elongační faktor b 4
D08.811.913.696.620.682.700.646 proteinkinasy řízené prolinem 1
D08.811.913.696.620.682.700.725 proteinkinasa C 139
D08.811.913.696.620.682.700.745 proteinkinasy PDK
D08.811.913.696.620.682.700.750 proteinkinasa D2
D08.811.913.696.620.682.700.755 protoonkogenní proteiny c-akt 123
D08.811.913.696.620.682.700.759 protoonkogenní proteiny c-bcr 19
D08.811.913.696.620.682.700.776 protoonkogenní proteiny c-pim-1 1
D08.811.913.696.620.682.700.780 PINK1 kinasa
D08.811.913.696.620.682.700.783 PDH-kinasa 1
D08.811.913.696.620.682.700.789 TGF-beta receptor I. typu 2
D08.811.913.696.620.682.700.795 TGF-beta receptor II. typu
D08.811.913.696.620.682.700.801 serin-threoninkinasy interagující s receptory 8
D08.811.913.696.620.682.700.814 kinázy asociované s Rho 26
D08.811.913.696.620.682.700.862 kinasy ribozomálního proteinu S6 1
D08.811.913.696.620.682.700.897 serin-threoninkinasa 3
D08.811.913.696.620.682.700.900 kinasa indukovaná sérem a glukokortikoidy
D08.811.913.696.620.682.700.931 TOR serin-threoninkinasy 196
D08.811.913.696.620.682.700.965 vakuolární třídící protein VPS15
D08.811.913.696.620.682.700.982 lysin-deficitní proteinkinasa WNK
D12 aminokyseliny, peptidy a proteiny 16
D12.776 proteiny 2 596
D12.776.476 intracelulární signální peptidy a proteiny 176
D12.776.476.563 protein-serin-threoninkinasy 274
D12.776.476.563.062 aktivinové receptory 6
D12.776.476.563.074 kinasy AMP aktivovaných proteinkinas 1
D12.776.476.563.085 proteinkinasy aktivované AMP 44
D12.776.476.563.097 ATM protein 92
D12.776.476.563.103 kinasy Aurora 4
D12.776.476.563.108 homolog Atg1 1
D12.776.476.563.109 receptory kostního morfogenetického proteinu 3
D12.776.476.563.125 proteinkinasy závislé na vápníku a kalmodulinu 10
D12.776.476.563.140 kaseinkinasy 1
D12.776.476.563.143 checkpoint kinasa 1 20
D12.776.476.563.145 checkpoint kinasa 2 51
D12.776.476.563.150 cyklickými nukleotidy regulované proteinkinasy
D12.776.476.563.250 proteinkinasa aktivovaná DNA 15
D12.776.476.563.275 kinasy podobné doublecortinu
D12.776.476.563.288 kinasy Dyrk
D12.776.476.563.294 kinasy Hippo
D12.776.476.563.300 kinasa eIF-2 8
D12.776.476.563.364 kinasy receptorů spřažených s G-proteiny 2
D12.776.476.563.397 kinázy zárodečného centra 2
D12.776.476.563.429 kinasy glykogensynthasy
D12.776.476.563.494 kinasa I-kappa B 9
D12.776.476.563.526 kinázy asociované s receptory interleukinu-1 3
D12.776.476.563.534 LRRK2 4
D12.776.476.563.542 Lim-kinasy 2
D12.776.476.563.550 proteinkinasa teplotního šoku 2
D12.776.476.563.554 MAP kinasy kinas (kinas) 48
D12.776.476.563.565 mitogenem aktivované proteinkinasy kinas 42
D12.776.476.563.567 mitogenem aktivované proteinkinasy 101
D12.776.476.563.576 DM-kinasa 2
D12.776.476.563.579 kinasa indukující NF-kappaB 1
D12.776.476.563.581 kinasy NEK 4
D12.776.476.563.586 onkogenní protein v-akt 5
D12.776.476.563.596 p21 aktivované kinasy 9
D12.776.476.563.606 fytochrom A 2
D12.776.476.563.616 polo-like kinasy
D12.776.476.563.626 pozitivní transkripční elongační faktor b 4
D12.776.476.563.646 proteinkinasy řízené prolinem 1
D12.776.476.563.725 proteinkinasa C 139
D12.776.476.563.745 proteinkinasy PDK
D12.776.476.563.750 proteinkinasa D2
D12.776.476.563.755 protoonkogenní proteiny c-akt 123
D12.776.476.563.759 protoonkogenní proteiny c-bcr 19
D12.776.476.563.776 protoonkogenní proteiny c-pim-1 1
D12.776.476.563.780 PINK1 kinasa
D12.776.476.563.783 PDH-kinasa 1
D12.776.476.563.789 TGF-beta receptor I. typu 2
D12.776.476.563.795 TGF-beta receptor II. typu
D12.776.476.563.801 serin-threoninkinasy interagující s receptory 8
D12.776.476.563.814 kinázy asociované s Rho 26
D12.776.476.563.862 kinasy ribozomálního proteinu S6 1
D12.776.476.563.897 serin-threoninkinasa 3
D12.776.476.563.900 kinasa indukovaná sérem a glukokortikoidy
D12.776.476.563.931 TOR serin-threoninkinasy 196
D12.776.476.563.965 vakuolární třídící protein VPS15
D12.776.476.563.982 lysin-deficitní proteinkinasa WNK

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