Biotransformation [biotransformace]

topical
798
Persistent link   https://www.medvik.cz/link/D001711
Definition

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

Annotation
restrict to chemical changes of exogenous substances; IM general only; coordinate NIM with specific drug /pharmacokin (IM) or /metab; do not confuse with BIODEGRADATION, ENVIRONMENTAL
DUI
D001711 MeSH Browser
CUI
M0002566
History note
70(66)
Public note
70

Allowable subheadings

DE
drug effects 46
GE
genetics 20
IM
immunology 6
PH
physiology 42
RE
radiation effects 8

G Phenomena and Processes
G03 Metabolism 1 203
G03 Metabolic Phenomena obsolete
G03.015 Absorption 273
G03.030 Acid-Base Equilibrium 447
G03.040 Acylation 24
G03.049 Aerobiosis 73
G03.059 Alkylation 65
G03.068 Amination 7
G03.078 Anaerobiosis 143
G03.087 Autotrophic Processes 13
G03.105 Biocatalysis 83
G03.143 Biological Transport 886
G03.162 Biotinylation 20
G03.171 Biotransformation 798
G03.171.224 Activation, Metabolic 12
G03.171.450 Inactivation, Metabolic 115
G03.180 Body Composition 542
G03.185 Brain Chemistry 424
G03.191 Carbohydrate Metabolism 493
G03.194 Catabolite Repression 2
G03.197 Cell Respiration 105
G03.208 Cyclization 55
G03.219 Dealkylation 4
G03.222 Deamination 10
G03.225 Decarboxylation 17
G03.230 Dimerization 102
G03.295 Energy Metabolism 1 587
G03.312 Enterohepatic Circulation 7
G03.328 Enzyme Activation 380
G03.344 Esterification 62
G03.360 Halogenation 45
G03.393 Heterotrophic Processes 20
G03.409 Hydrogenation 24
G03.425 Hydroxylation 65
G03.442 Insulin Secretion 25
G03.458 Lipid Metabolism 1 398
G03.474 Melanogenesis
G03.490 Metabolic Clearance Rate 224
G03.493 Metabolic Networks and Pathways 148
G03.500 Metabolome 137
G03.558 Nitrosation 12
G03.615 Osmoregulation 11
G03.673 Oxidative Stress 2 139
G03.680 Oxygen Consumption 1 193
G03.707 Oxygen Saturation 21
G03.734 Peptide Biosynthesis 43
G03.787 Pharmacokinetics 757
G03.787.024 Absorption 273
G03.787.101 Area Under Curve 170
G03.787.151 Biological Availability 288
G03.787.225 Biotransformation 798
G03.787.225.224 Activation, Metabolic 12
G03.787.225.450 Inactivation, Metabolic 115
G03.787.297 Drug Elimination Routes 7
G03.787.321 Drug Liberation 162
G03.787.559 Therapeutic Equivalency 174
G03.787.917 Tissue Distribution 271
G03.796 Phosphorylation 723
G03.800 Phototrophic Processes 25
G03.804 Prenylation 14
G03.808 Protein Binding 1 256
G03.812 Proteolysis 130
G03.816 Proteostasis 7
G03.818 Proteotoxic Stress
G03.820 Renin-Angiotensin System 681
G03.839 RNA Processing, Post-Transcriptional 57
G03.857 Secretory Rate 28
G03.893 Toxicokinetics 8
G07 Physiological Phenomena 176
G07.690 Pharmacological and Toxicological Phenomena 59
G07.690.725 Pharmacokinetics 757
G07.690.725.015 Absorption 273
G07.690.725.064 Area Under Curve 170
G07.690.725.129 Biological Availability 288
G07.690.725.225 Biotransformation 798
G07.690.725.225.224 Activation, Metabolic 12
G07.690.725.225.450 Inactivation, Metabolic 115
G07.690.725.249 Chronopharmacokinetics
G07.690.725.297 Drug Elimination Routes 7
G07.690.725.321 Drug Liberation 162
G07.690.725.513 Metabolic Clearance Rate 224
G07.690.725.898 Therapeutic Equivalency 174
G07.690.725.949 Tissue Distribution 271

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