Ferrochelatase [ferrochelatasa]
- Terms
-
Fe chelatáza
ferochelatáza
ferrochelatáza
hemsyntáza
hemsyntetáza
Zn chelatasa
Zn chelatáza
-
Heme Synthetase
Porphyrin-Metal Chelatase
Protoheme Ferro-Lyase
Zinc Chelatase
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
- DUI
- D005294 MeSH Browser
- CUI
- M0008356
- CAS
- Protoheme ferro-lyase
- Previous indexing
- Porphyrins (1966-1976); Lyases (1966-1976); Iron (1966-1976); Protoporphyrins (1975-1976)
- History note
- 1991(1977); use LYASES 1977-1990
- Public note
- 1991; see LYASES 1977-1990
Combination
- deficiency
- Protoporphyria, Erythropoietic
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 3
- CL
- classification
- DE
- drug effects
- EC
- economics
- GE
- genetics 5
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 6
- PK
- pharmacokinetics 1
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
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