Ferrochelatase [ferrochelatasa]

topical
11
Terms

Fe chelatáza
ferochelatáza
ferrochelatáza
hemsyntáza
hemsyntetáza
Zn chelatasa
Zn chelatáza

 

Heme Synthetase
Porphyrin-Metal Chelatase
Protoheme Ferro-Lyase
Zinc Chelatase

Persistent link   https://www.medvik.cz/link/D005294
Definition

A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.

DUI
D005294 MeSH Browser
CUI
M0008356
CAS
Protoheme ferro-lyase
Previous indexing
Lyases (1966-1976); Iron (1966-1976); Porphyrins (1966-1976); Protoporphyrins (1975-1976)
History note
1991(1977); use LYASES 1977-1990
Public note
1991; see LYASES 1977-1990

Combination

deficiency
Protoporphyria, Erythropoietic

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 1
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 3
CL
classification 0
DE
drug effects 0
EC
economics 0
GE
genetics 5
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 6
PK
pharmacokinetics 1
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.520 Lyases 22
D08.811.520.224 Carbon-Carbon Lyases 4
D08.811.520.232 Carbon-Nitrogen Lyases 1
D08.811.520.241 Carbon-Oxygen Lyases 1
D08.811.520.300 Carbon-Sulfur Lyases 13
D08.811.520.500 Ferrochelatase 11
D08.811.520.650 Phosphorus-Oxygen Lyases 4
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.157 Carrier Proteins 546
D12.776.157.427 Iron-Binding Proteins 31
D12.776.157.427.374 Nonheme Iron Proteins 4
D12.776.157.427.374.375 Iron-Sulfur Proteins 27
D12.776.157.427.374.375.025 Adrenodoxin
D12.776.157.427.374.375.150 Ferredoxin-Nitrite Reductase
D12.776.157.427.374.375.275 Ferredoxins 14
D12.776.157.427.374.375.863 Electron Transport Complex I 44
D12.776.157.427.374.375.909 Electron Transport Complex II 20
D12.776.157.427.374.375.954 Electron Transport Complex III 19
D12.776.157.427.374.375.957 Ferrochelatase 11
D12.776.157.427.374.375.959 Frataxin 2
D12.776.157.427.374.375.960 Iron Regulatory Protein 1 1
D12.776.157.427.374.375.961 Iron Regulatory Protein 2 2
D12.776.157.427.374.375.977 Nitrate Reductase (NAD(P)H)
D12.776.157.427.374.375.988 Nitrate Reductase (NADPH) 1
D12.776.556 Metalloproteins 30
D12.776.556.579 Iron-Binding Proteins 31
D12.776.556.579.374 Nonheme Iron Proteins 4
D12.776.556.579.374.375 Iron-Sulfur Proteins 27
D12.776.556.579.374.375.025 Adrenodoxin
D12.776.556.579.374.375.140 Electron Transport Complex I 44
D12.776.556.579.374.375.141 Electron Transport Complex II 20
D12.776.556.579.374.375.142 Electron Transport Complex III 19
D12.776.556.579.374.375.150 Ferredoxin-Nitrite Reductase
D12.776.556.579.374.375.275 Ferredoxins 14
D12.776.556.579.374.375.617 Ferrochelatase 11
D12.776.556.579.374.375.789 Frataxin 2
D12.776.556.579.374.375.960 Iron Regulatory Protein 1 1
D12.776.556.579.374.375.962 Iron Regulatory Protein 2 2
D12.776.556.579.374.375.977 Nitrate Reductase (NAD(P)H)
D12.776.556.579.374.375.988 Nitrate Reductase (NADPH) 1
D12.776.575 Mitochondrial Proteins 208
D12.776.575.093 Aldehyde Dehydrogenase, Mitochondrial 5
D12.776.575.140 ATPase Inhibitory Protein
D12.776.575.186 Creatine Kinase, Mitochondrial Form 3
D12.776.575.280 DNA Polymerase gamma 3
D12.776.575.374 Endopeptidase Clp
D12.776.575.562 Ferrochelatase 11
D12.776.575.609 Frataxin 2
D12.776.575.656 High-Temperature Requirement A Serine Peptidase 2
D12.776.575.750 Mitochondrial Membrane Transport Proteins 35
D12.776.575.758 Mitochondrial Processing Peptidase
D12.776.575.765 Mitochondrial Trifunctional Protein 2
D12.776.575.781 Nucleoside Diphosphate Kinase D
D12.776.575.812 Peroxiredoxin III 2
D12.776.575.844 Prohibitins 1
D12.776.575.875 Sirtuin 3 4

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