Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.

DUI

D009173 MeSH Browser

CUI

M0014304

CAS

-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-

Previous indexing

Antibiotics, Antineoplastic (1967-1971); Caproates (1967-1971)

History note

2017 (1999)

Public note

2017; MYCOPHENOLATE MOFETIL was indexed under MYCOPHENOLIC ACID 1990-2016