Pregnancy-Associated Plasma Protein-A [těhotenský plazmatický protein A]
topical
63
- Terms
-
PAPP-A
proteáza IGFBP-4
-
IGFBP-4 Metalloproteinase
IGFBP-4 Protease
IGFBP-4-Specific Proteinase
Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
Insulin-Like-Growth Factor Binding Protein-4 Protease
PAPP-A
PAPP-alpha
Pregnancy Associated alpha Plasma Protein
Pregnancy-Associated alpha-Plasma Protein
Persistent link
https://www.medvik.cz/link/D011266
Definition
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
- DUI
- D011266 MeSH Browser
- CUI
- M0017493
- Previous indexing
- Glycoproteins (1966-1979); Pregnancy (1966-1979); Alpha Globulins (1966-1979); Alpha Macroglobulins (1976-1979); Blood Proteins (1966-1979)
- History note
- 2004 (1996)
- Public note
- 2004; for PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN see PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN 1991-2003, see PREGNANCY PROTEINS 1980-1990
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AG
- agonists 0
- AA
- analogs & derivatives 1
- AN
- analysis 30
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 4
- EC
- economics 0
- GE
- genetics 4
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 2
- ME
- metabolism 18
- PK
- pharmacokinetics 1
- PD
- pharmacology 0
- PH
- physiology 1
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D08.811.277.656.300.480.563
Mitochondrial Processing Peptidase
D08.811.277.656.300.480.664
Procollagen N-Endopeptidase
D08.811.277.656.675.374.563
Mitochondrial Processing Peptidase
D08.811.277.656.675.374.664
Procollagen N-Endopeptidase
D12.776.780.675
Pregnancy-Associated alpha 2-Macroglobulins