Shwartzman Phenomenon [Shwartzmanův fenomén]
- Terms
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Shwartzmanova reakce
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Schwartzman Phenomenon
Schwartzman Reaction
Shwartzman Reaction
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
- DUI
- D012790 MeSH Browser
- CUI
- M0019807
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