Trimethoprim [trimethoprim]
- Terms
-
Proloprim
Trimpex
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
- Annotation
- consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria
- DUI
- D014295 MeSH Browser
- CUI
- M0021991
- CAS
- 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
- Previous indexing
- Pyrimidines (1966-1971); Anti-Infective Agents (1966-1971); Folic Acid Antagonists (1966-1971)
- History note
- 1974 (1972)
- Public note
- 1974
Allowable subheadings
- AD
- administration & dosage 15
- AE
- adverse effects 10
- AG
- agonists
- AA
- analogs & derivatives 2
- AN
- analysis 5
- AI
- antagonists & inhibitors
- BL
- blood 1
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 3
- PK
- pharmacokinetics 4
- PD
- pharmacology 6
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 22
- TO
- toxicity 3
- UR
- urine 1
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