Complement C5a [komplement C5a]
- Terms
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komplement 5a
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C5a Complement
Complement 5a
Complement Component 5a
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
- DUI
- D015936 MeSH Browser
- CUI
- M0024381
- CAS
- Complement C5a
- Previous indexing
- Anaphylatoxins (1977-1989); Complement (1972-1975); Complement 5 (1975-1989)
- History note
- 2006 (1990)
- Public note
- 2006; see COMPLEMENT 5A 1990-2005
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis 1
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
C5aRAD Chemical MeSH Browser
complement C5a, (65-74), Tyr(65)-Phe(67)-Pro(69,71)-Ala(73)- Chemical MeSH Browser