Zalcitabine [dideoxycytidin]
topical
8
- Terms
-
2',3'-Dideoxycytidine
ddC (Antiviral)
Dideoxycytidine
Hivid
HIVID Roche
NSC-606170
Persistent link
https://www.medvik.cz/link/D016047
Definition
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
- DUI
- D016047 MeSH Browser
- CUI
- M0024532
- CAS
- Cytidine, 2',3'-dideoxy-
- Previous indexing
- Dideoxynucleosides (1989); Deoxycytidine/analogs & derivatives (1986-1989)
- History note
- 94; was DIDEOXYCYTIDINE 1990-93
- Online note
- use ZALCITABINE to search DIDEOXYCYTIDINE 1990-93
- Public note
- 94; was DIDEOXYCYTIDINE 1990-93
Allowable subheadings
- AD
- administration & dosage 3
- AE
- adverse effects 2
- AG
- agonists
- AA
- analogs & derivatives 2
- AN
- analysis
- AI
- antagonists & inhibitors
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 2
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics 2
- PD
- pharmacology 4
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 5
- TO
- toxicity
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs