Didanosine [dideoxyinosin]
topical
6
- Terms
-
2',3'-dideoxyinosin
-
2',3'-Dideoxyinosine
ddI (Antiviral)
Dideoxyinosine
NSC-612049
Videx
Persistent link
https://www.medvik.cz/link/D016049
Definition
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
- DUI
- D016049 MeSH Browser
- CUI
- M0024535
- CAS
- Inosine, 2',3'-dideoxy-
- Previous indexing
- Dideoxynucleosides (1989); Inosine/analogs & derivatives (1987-1989)
- History note
- 92; was DIDEOXYINOSINE 1990-91
- Online note
- use DIDANOSINE to search DIDEOXYINOSINE 1990-91
- Public note
- 92; was DIDEOXYINOSINE 1990-91
Allowable subheadings
- AD
- administration & dosage 2
- AE
- adverse effects 1
- AG
- agonists 0
- AA
- analogs & derivatives 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 1
- CL
- classification 0
- EC
- economics 0
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 0
- PK
- pharmacokinetics 1
- PD
- pharmacology 2
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 3
- TO
- toxicity 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs