Lymphocyte Function-Associated Antigen-1 [antigen-1 spojený s lymfocytární funkcí]
topical
7
- Terms
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Integrin alphaLbeta2
Leukocyte Function Associated Antigen-1
LFA-1
Persistent link
https://www.medvik.cz/link/D016169
Definition
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
- DUI
- D016169 MeSH Browser
- CUI
- M0024683
- Previous indexing
- Antigens, Differentiation (1988-1990); Receptors, Leukocyte-Adhesion (1989-1990)
- History note
- 1991
- Public note
- 1991
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AN
- analysis 0
- BI
- biosynthesis 0
- BL
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- CF
- cerebrospinal fluid 0
- CH
- chemistry 1
- CL
- classification 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 0
- HI
- history 0
- IM
- immunology 2
- IP
- isolation & purification 0
- ME
- metabolism 2
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
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Occurrences in Medvik records