Lupus Coagulation Inhibitor [lupusový inhibiční faktor koagulace]
- Terms
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lupus antikoagulans
lupusová antikoagulační autoprotilátka
lupusové antikoagulační autoprotilátky
lupusové antikoagulans
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Anticoagulant, Lupus
Coagulation Inhibitor, Lupus
Inhibitor, Lupus Coagulation
Lupus Anticoagulant
Lupus Anticoagulant Autoantibodies
Lupus Anticoagulant Autoantibody
An antiphospholipid antibody found in association with a variety of diseases (e.g., SYSTEMIC LUPUS ERYTHEMATOSUS and ANTIPHOSPHOLIPID SYNDROME) as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
- DUI
- D016682 MeSH Browser
- CUI
- M0025416
- Previous indexing
- Autoantibodies (1966-1991); Blood Coagulation Factors (1966-1991)
- History note
- 92; was LUPUS COAGULATION INHIBITOR (NM) 1978-91
- Online note
- use LUPUS COAGULATION INHIBITOR (NM) to search LUPUS COAGULATION INHIBITOR 1980-91
- Public note
- 92; LUPUS COAGULATION INHIBITOR was indexed under BLOOD COAGULATION FACTORS/immunology 1986-91 & BLOOD COAGULATION FACTORS/antagonists & inhibitors 1978-88
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects 2
- AN
- analysis 8
- BI
- biosynthesis
- BL
- blood 13
- CF
- cerebrospinal fluid
- CH
- chemistry
- CL
- classification
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology 4
- IP
- isolation & purification 2
- ME
- metabolism 2
- PD
- pharmacology
- PH
- physiology 1
- PO
- poisoning
- RE
- radiation effects
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine