Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).

DUI

D020570 MeSH Browser

CUI

M0328534

Previous indexing

Genes, Viral (1983-1999); Oncogenes (1983-1999)

History note

2000; use ONCOGENES 1985-1999

Public note

2000; use ONCOGENES 1985-1999