Selective Estrogen Receptor Modulators [selektivní modulátory estrogenních receptorů]
- Terms
-
modulátor receptoru pro estrogen
receptory estrogenů - selektivní modulátory
selektivní modulátor estrogenních receptorů
selektivní modulátory receptorů pro estrogeny
SERM
SERMs
-
Estrogen Receptor Modulator, Selective
Estrogen Receptor Modulators, Selective
Selective Estrogen Receptor Modulator
SERM
SERMs
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
- Annotation
- do not confuse with ESTROGEN RECEPTOR MODULATORS
- DUI
- D020845 MeSH Browser
- CUI
- M0328354
- Previous indexing
- Receptors, Estrogen (1996-1999)
- History note
- 2000
- Public note
- 2000
Allowable subheadings
- AD
- administration & dosage 25
- AE
- adverse effects 20
- AG
- agonists 0
- AN
- analysis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 1
- CH
- chemistry 6
- CL
- classification 4
- EC
- economics 0
- HI
- history 0
- IM
- immunology 1
- IP
- isolation & purification 0
- ME
- metabolism 3
- PK
- pharmacokinetics 4
- PD
- pharmacology 54
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 94
- TO
- toxicity 0
- UR
- urine 0