Integrin alpha Chains [alfa řetězce integrinu]

topical
5
Terms

alfa integriny
alfa podjednotky integrinu
integrin - řetězce alfa

 

alpha Integrins
Integrin alpha Subunits

Persistent link   https://www.medvik.cz/link/D039001
Definition

The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.

DUI
D039001 MeSH Browser
CUI
M0417909
Previous indexing
Integrins (1966-2002)
History note
2003
Public note
2003

Allowable subheadings

AD
administration & dosage 1
AG
agonists
AN
analysis
AI
antagonists & inhibitors 2
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects 1
GE
genetics 1
HI
history
IM
immunology 1
IP
isolation & purification
ME
metabolism 1
PH
physiology
RE
radiation effects
TU
therapeutic use 1
UL
ultrastructure

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 190
D04 Polycyclic Compounds 65
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D09 Carbohydrates 724
D10 Lipids 2 528
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.543 Membrane Proteins 850
D12.776.543.750 Receptors, Cell Surface 511
D12.776.543.750.705 Receptors, Immunologic 129
D12.776.543.750.705.408 Integrins 118
D12.776.543.750.705.408.100 Integrin alpha Chains 5
D12.776.543.750.705.408.100.100 CD11a Antigen 2
D12.776.543.750.705.408.100.150 CD11b Antigen 32
D12.776.543.750.705.408.100.200 CD11c Antigen 8
D12.776.543.750.705.408.100.300 Integrin alpha1
D12.776.543.750.705.408.100.350 Integrin alpha2 3
D12.776.543.750.705.408.100.400 Integrin alpha3 1
D12.776.543.750.705.408.100.450 Integrin alpha4 46
D12.776.543.750.705.408.100.500 Integrin alpha5 1
D12.776.543.750.705.408.100.550 Integrin alpha6 3
D12.776.543.750.705.408.100.900 Integrin alphaV 4
D12.776.543.750.705.408.100.950 Platelet Membrane Glycoprotein IIb 2
D12.776.543.750.705.408.200 Integrin beta Chains 3
D12.776.543.750.705.408.460 Receptors, Cytoadhesin 2
D12.776.543.750.705.408.495 Receptors, Fibrinogen 1
D12.776.543.750.705.408.530 Receptors, Fibronectin 2
D12.776.543.750.705.408.600 Receptors, Leukocyte-Adhesion 6
D12.776.543.750.705.408.850 Receptors, Very Late Antigen
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 110
D26 Pharmaceutical Preparations 7 045
D27 Chemical Actions and Uses 374

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