A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

DUI

D039103 MeSH Browser

CUI

M0103425

Previous indexing

RNA-Binding Proteins (1995-2002)

History note

2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002

Public note

2003; PAB II was indexed under RNA-BINDING PROTEINS 1995-2002; PABP2 GENE PRODUCT & PABP2 PROTEIN were indexed under RNA-BINDING PROTEINS 1999-2002; PABP2 was indexed under RNA-BINDING PROTEINS 2000-2002