alpha-Mannosidase [alfa-mannosidasa]
- Terms
-
alfa-D-mannosidáza
alfa-mannosidáza
alfa-mannosidáza B
LAMAN
lyzozomální alfa-mannosidasa
lyzozomální alfa-mannosidáza
-
alpha Mannosidase B
alpha-D-Mannosidase
alpha-D-Mannoside Mannohydrolase
LAMAN
Lysosomal alpha-Mannosidase
Neutral alpha-Mannosidase
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
- Annotation
- /DEFIC: consider also ALPHA-MANNOSIDOSIS
- DUI
- D043323 MeSH Browser
- CUI
- M0085930
- RN
- EC 3.2.1.24
- Previous indexing
- Mannosidases (1980-2003)
- History note
- 2004; use ALPHA-MANNOSIDASE (NM) 1980-2003
- Public note
- 2004; ALPHA-MANNOSIDASE was indexed under MANNOSIDASES 1980-2003
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
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- chemistry 0
- CL
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- ME
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- urine 0