Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.

DUI

D045585 MeSH Browser

CUI

M0228928

Previous indexing

Endodeoxyribonucleases (1994-2003)

History note

2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003

Public note

2004; FLAP ENDONUCLEASES was indexed under ENDODEOYRIBONUCLEASES 1994-2003; FEN1 PROTEIN was indexed under EXODEOXYRIBNUCLEASES 1997-2003; RTH-1 NUCLEASE was indexed under EXODEOXYRIBNUCLEASES 1996-2003