Caspase 8 [kaspasa 8]

topical
20
Terms

kaspasa-8
kaspáza 8
pro-kaspasa-8
prokaspasa-8
prokaspáza 8
proteasa CAP4
proteasa Mch5
protein FLICE
protein MACH

 

CAP4 Protease
Caspase-8
FLICE Protein
MACH Protein
Mch5 Protease
Pro-Caspase-8
Procaspase-8

Persistent link   https://www.medvik.cz/link/D053181
Definition

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

DUI
D053181 MeSH Browser
CUI
M0283158
History note
2007(2000)
Public note
2007; CASPASE 8 was indexed under CASPASES 1999-2006 & under CYSTEINE PROTEINASES 1997-1998

Combination

antagonists & inhibitors
Caspase Inhibitors
deficiency
Alstrom Syndrome

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis 1
BI
biosynthesis 1
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects 1
EC
economics
GE
genetics 4
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 13
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 549
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 559
D08.811.277.656.262 Cysteine Proteases 12
D08.811.277.656.262.500 Cysteine Endopeptidases 44
D08.811.277.656.262.500.126 Caspases 158
D08.811.277.656.262.500.126.550 Caspases, Initiator 3
D08.811.277.656.262.500.126.550.100 Caspase 1 16
D08.811.277.656.262.500.126.550.200 Caspase 2 12
D08.811.277.656.262.500.126.550.800 Caspase 8 20
D08.811.277.656.262.500.126.550.900 Caspase 9 24
D08.811.277.656.262.500.126.550.910 Caspase 10 2
D08.811.277.656.262.500.126.550.920 Caspase 12 3
D08.811.277.656.300 Endopeptidases 211
D08.811.277.656.300.200 Cysteine Endopeptidases 44
D08.811.277.656.300.200.126 Caspases 158
D08.811.277.656.300.200.126.550 Caspases, Initiator 3
D08.811.277.656.300.200.126.550.100 Caspase 1 16
D08.811.277.656.300.200.126.550.200 Caspase 2 12
D08.811.277.656.300.200.126.550.800 Caspase 8 20
D08.811.277.656.300.200.126.550.900 Caspase 9 24
D08.811.277.656.300.200.126.550.910 Caspase 10 2
D08.811.277.656.300.200.126.550.920 Caspase 12 3
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 579
D12.776.157 Carrier Proteins 546
D12.776.157.057 Adaptor Proteins, Signal Transducing 182
D12.776.157.057.018 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.157.057.018.024 CASP8 and FADD-Like Apoptosis Regulating Protein 5
D12.776.157.057.018.037 Caspase 8 20
D12.776.157.057.018.050 CRADD Signaling Adaptor Protein
D12.776.157.057.018.100 Edar-Associated Death Domain Protein 1
D12.776.157.057.018.200 Fas-Associated Death Domain Protein 2
D12.776.157.057.018.400 Receptor-Interacting Protein Serine-Threonine Kinases 7
D12.776.157.057.018.600 TNF Receptor-Associated Death Domain Protein
D12.776.476 Intracellular Signaling Peptides and Proteins 175
D12.776.476.024 Adaptor Proteins, Signal Transducing 182
D12.776.476.024.320 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.024.320.025 Caspase 8 20
D12.776.476.024.320.050 CRADD Signaling Adaptor Protein
D12.776.476.024.320.100 Edar-Associated Death Domain Protein 1
D12.776.476.024.320.550 Fas-Associated Death Domain Protein 2
D12.776.476.024.320.662 Receptor-Interacting Protein Serine-Threonine Kinases 7
D12.776.476.024.320.775 TNF Receptor-Associated Death Domain Protein
D12.776.476.075 Apoptosis Regulatory Proteins 79
D12.776.476.075.405 Caspases 158
D12.776.476.075.405.550 Caspases, Initiator 3
D12.776.476.075.405.550.100 Caspase 1 16
D12.776.476.075.405.550.200 Caspase 2 12
D12.776.476.075.405.550.800 Caspase 8 20
D12.776.476.075.405.550.900 Caspase 9 24
D12.776.476.075.405.550.910 Caspase 10 2
D12.776.476.075.405.550.920 Caspase 12 3
D12.776.476.075.421 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.075.421.024 CASP8 and FADD-Like Apoptosis Regulating Protein 5
D12.776.476.075.421.037 Caspase 8 20
D12.776.476.075.421.050 CRADD Signaling Adaptor Protein
D12.776.476.075.421.100 Edar-Associated Death Domain Protein 1
D12.776.476.075.421.200 Fas-Associated Death Domain Protein 2
D12.776.476.075.421.400 Receptor-Interacting Protein Serine-Threonine Kinases 7
D12.776.476.075.421.600 TNF Receptor-Associated Death Domain Protein

CASP8 protein, human Chemical MeSH Browser

Casp8 protein, mouse Chemical MeSH Browser

Casp8 protein, rat Chemical MeSH Browser

Add