Presenilin-1 [presenilin-1]
- Terms
-
presenilin 1
protein S182
-
Presenilin 1
S182 Protein
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
- DUI
- D053764 MeSH Browser
- CUI
- M0248671
- Previous indexing
- Alzheimer Disease (1995-2006); Membrane Proteins (1995-2006)
- History note
- 2007
- Public note
- 2007; was indexed under MEMBRANE PROTEINS 1995-2006
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 10
- HI
- history
- IM
- immunology
- IP
- isolation & purification 1
- ME
- metabolism 3
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
LATS1-PSEN1 fusion protein, human Chemical MeSH Browser
PSEN1 protein, human Chemical MeSH Browser
Psen1 protein, rat Chemical MeSH Browser
Psen1 protein, zebrafish Chemical MeSH Browser
presenilin 1, mouse Chemical MeSH Browser