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Autor
Abrahamsson, Bertil 1 Artursson, Per 1 Augustijns, Patrick 1 Batchelor, Hannah 1 Berben, Philippe 1 Bernkop-Schnürch, Andreas 1 Butler, James 1 Ceulemans, Jens 1 Davies, Nigel 1 De Wildt, Saskia N 1 Dupont, Didier 1 Flaten, Gøril Eide 1 Fotaki, Nikoletta 1 Griffin, Brendan T 1 Jannin, Vincent 1 Keemink, Janneke 1 Kesisoglou, Filippos 1 Koziolek, Mirko 1 Kuentz, Martin 1 Mackie, Alan 1
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Pracoviště
Abbvie Deutschland GmbH and Co KG Lud... 1 Advanced Drug Delivery Pharmaceutical... 1 College of Pharmaceutical Sciences Ri... 1 Department of Chemical and Pharmaceut... 1 Department of Pharmaceutical Technolo... 1 Department of Pharmaceutical and Phar... 1 Department of Pharmacology and Toxico... 1 Department of Pharmacy National and K... 1 Department of Pharmacy UiT The Arctic... 1 Department of Pharmacy University of ... 1 Department of Pharmacy Uppsala Univer... 1 Department of Pharmacy and Pharmacolo... 1 Drug Product Design Pfizer PGRD Sandw... 1 F Hoffmann La Roche Ltd Basel Switzer... 1 Faculty of Medicine University of Med... 1 Faculty of Pharmacy Charles Universit... 1 Food Colour and Quality Laboratory Ar... 1 GlaxoSmithKline Research and Developm... 1 INRAE Institut Agro STLO Rennes France 1 Institute for Pharma Technology Unive... 1
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Autor
Abrahamsson, Bertil 1 Artursson, Per 1 Augustijns, Patrick 1 Batchelor, Hannah 1 Berben, Philippe 1 Bernkop-Schnürch, Andreas 1 Butler, James 1 Ceulemans, Jens 1 Davies, Nigel 1 De Wildt, Saskia N 1 Dupont, Didier 1 Flaten, Gøril Eide 1 Fotaki, Nikoletta 1 Griffin, Brendan T 1 Jannin, Vincent 1 Keemink, Janneke 1 Kesisoglou, Filippos 1 Koziolek, Mirko 1 Kuentz, Martin 1 Mackie, Alan 1
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Pracoviště
Abbvie Deutschland GmbH and Co KG Lud... 1 Advanced Drug Delivery Pharmaceutical... 1 College of Pharmaceutical Sciences Ri... 1 Department of Chemical and Pharmaceut... 1 Department of Pharmaceutical Technolo... 1 Department of Pharmaceutical and Phar... 1 Department of Pharmacology and Toxico... 1 Department of Pharmacy National and K... 1 Department of Pharmacy UiT The Arctic... 1 Department of Pharmacy University of ... 1 Department of Pharmacy Uppsala Univer... 1 Department of Pharmacy and Pharmacolo... 1 Drug Product Design Pfizer PGRD Sandw... 1 F Hoffmann La Roche Ltd Basel Switzer... 1 Faculty of Medicine University of Med... 1 Faculty of Pharmacy Charles Universit... 1 Food Colour and Quality Laboratory Ar... 1 GlaxoSmithKline Research and Developm... 1 INRAE Institut Agro STLO Rennes France 1 Institute for Pharma Technology Unive... 1
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Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
- MeSH
- aplikace orální MeSH
- gastrointestinální trakt metabolismus MeSH
- interakce mezi potravou a léky MeSH
- intestinální absorpce * MeSH
- léčivé přípravky chemie metabolismus MeSH
- lidé MeSH
- počítačová simulace MeSH
- příprava léků MeSH
- zvířata MeSH
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- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
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Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.