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Autor
Bartram, Claus R 1 Basso, Giuseppe 1 Biondi, Andrea 1 Bleckmann, Kirsten 1 Borkhardt, Arndt 1 Bornhauser, Beat 1 Bourquin, Jean-Pierre 1 Cario, Gunnar 1 Cavé, Hélène 1 Cazzaniga, Giovanni 1 Dagdan, Elif 1 Dörge, Petra 1 Eckert, Cornelia 1 Franke, Andre 1 Groeneveld-Krentz, Stefanie 1 Haas, Oskar A 1 Hinze, Laura 1 Houlston, Richard S 1 Izraeli, Shai 1 Junk, Stefanie V 1
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Pracoviště
Anja Möricke Kirsten Bleckmann Denis ... 1 Arndt Borkhardt Heinrich Heine Univer... 1 Britt Sabina Petersen and Andre Frank... 1 Chiara Palmi Giovanni Cazzaniga and A... 1 Cornelia Eckert and Stefanie Groeneve... 1 Geertruy te Kronnie and Giuseppe Bass... 1 Hélène Cavé Robert Debré Hospital and... 1 Jean Pierre Bourquin and Beat Bornhau... 1 Maria Grazia Valsecchi University of ... 1 Marketa Zaliova Charles University an... 1 Martin Stanulla Elif Dagdan Stefanie ... 1 Oskar A Haas and Renate Panzer Grümay... 1 Petra Dörge German Center for Infecti... 1 Richard S Houlston The Institute of C... 1 Rolf Koehler Claus R Bartram Andreas ... 1 Shai Izraeli Sheba Medical Center Tel... 1 Wolf Dieter Ludwig HELIOS Clinic Berl... 1
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- Vlastník
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Autor
Bartram, Claus R 1 Basso, Giuseppe 1 Biondi, Andrea 1 Bleckmann, Kirsten 1 Borkhardt, Arndt 1 Bornhauser, Beat 1 Bourquin, Jean-Pierre 1 Cario, Gunnar 1 Cavé, Hélène 1 Cazzaniga, Giovanni 1 Dagdan, Elif 1 Dörge, Petra 1 Eckert, Cornelia 1 Franke, Andre 1 Groeneveld-Krentz, Stefanie 1 Haas, Oskar A 1 Hinze, Laura 1 Houlston, Richard S 1 Izraeli, Shai 1 Junk, Stefanie V 1
- Organizace
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Pracoviště
Anja Möricke Kirsten Bleckmann Denis ... 1 Arndt Borkhardt Heinrich Heine Univer... 1 Britt Sabina Petersen and Andre Frank... 1 Chiara Palmi Giovanni Cazzaniga and A... 1 Cornelia Eckert and Stefanie Groeneve... 1 Geertruy te Kronnie and Giuseppe Bass... 1 Hélène Cavé Robert Debré Hospital and... 1 Jean Pierre Bourquin and Beat Bornhau... 1 Maria Grazia Valsecchi University of ... 1 Marketa Zaliova Charles University an... 1 Martin Stanulla Elif Dagdan Stefanie ... 1 Oskar A Haas and Renate Panzer Grümay... 1 Petra Dörge German Center for Infecti... 1 Richard S Houlston The Institute of C... 1 Rolf Koehler Claus R Bartram Andreas ... 1 Shai Izraeli Sheba Medical Center Tel... 1 Wolf Dieter Ludwig HELIOS Clinic Berl... 1
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Stanulla, Martin
Autor Stanulla, Martin Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Dagdan, Elif
Autor Dagdan, Elif Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Zaliova, Marketa
Autor Zaliova, Marketa Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Möricke, Anja
Autor Möricke, Anja Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Palmi, Chiara
Autor Palmi, Chiara Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Cazzaniga, Giovanni
Autor Cazzaniga, Giovanni Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Eckert, Cornelia
Autor Eckert, Cornelia Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Te Kronnie, Geertruy
Autor Te Kronnie, Geertruy Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Bourquin, Jean-Pierre
Autor Bourquin, Jean-Pierre Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
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Bornhauser, Beat
Autor Bornhauser, Beat Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School Petra Dörge, German Center for Infection Research, Hannover Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo Maria Grazia Valsecchi, University of Milano-Bicocca, Monza Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom
Open Access Digital Library od 1999-01-01
PubMed
29498923
DOI
10.1200/jco.2017.74.3617
Knihovny.cz E-zdroje
Purpose Somatic deletions that affect the lymphoid transcription factor-coding gene IKZF1 have previously been reported as independently associated with a poor prognosis in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL). We have now refined the prognostic strength of IKZF1 deletions by analyzing the effect of co-occurring deletions. Patients and Methods The analysis involved 991 patients with BCP ALL treated in the Associazione Italiana Ematologia ed Oncologia Pediatrica-Berlin-Frankfurt-Muenster (AIEOP-BFM) ALL 2000 trial with complete information for copy number alterations of IKZF1, PAX5, ETV6, RB1, BTG1, EBF1, CDKN2A, CDKN2B, Xp22.33/Yp11.31 (PAR1 region; CRLF2, CSF2RA, and IL3RA), and ERG; replication of findings involved 417 patients from the same trial. Results IKZF1 deletions that co-occurred with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG deletion conferred the worst outcome and, consequently, were grouped as IKZF1plus. The IKZF1plus group comprised 6% of patients with BCP ALL, with a 5-year event-free survival of 53 ± 6% compared with 79 ± 5% in patients with IKZF1 deletion who did not fulfill the IKZF1plus definition and 87 ± 1% in patients who lacked an IKZF1 deletion ( P ≤ .001). Respective 5-year cumulative relapse incidence rates were 44 ± 6%, 11 ± 4%, and 10 ± 1% ( P ≤ .001). Results were confirmed in the replication cohort, and multivariable analyses demonstrated independence of IKZF1plus. The IKZF1plus prognostic effect differed dramatically in analyses stratified by minimal residual disease (MRD) levels after induction treatment: 5-year event-free survival for MRD standard-risk IKZF1plus patients was 94 ± 5% versus 40 ± 10% in MRD intermediate- and 30 ± 14% in high-risk IKZF1plus patients ( P ≤ .001). Corresponding 5-year cumulative incidence of relapse rates were 6 ± 6%, 60 ± 10%, and 60 ± 17% ( P ≤ .001). Conclusion IKZF1plus describes a new MRD-dependent very-poor prognostic profile in BCP ALL. Because current AIEOP-BFM treatment is largely ineffective for MRD-positive IKZF1plus patients, new experimental treatment approaches will be evaluated in our upcoming trial AIEOP-BFM ALL 2017.
- MeSH
- aktivátorový protein specifický pro B-buňky genetika MeSH
- delece genu * MeSH
- dítě MeSH
- inhibitor p15 cyklin-dependentní kinasy genetika MeSH
- inhibitor p16 cyklin-dependentní kinasy genetika MeSH
- lidé MeSH
- pre-B-buněčná leukemie genetika patologie MeSH
- prognóza MeSH
- receptor PAR-1 genetika MeSH
- reziduální nádor genetika patologie MeSH
- transkripční faktor Ikaros genetika MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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