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Autor
Badr, Nahla 1 Berditchevski, Fedor 1 Danial, Irini 1 Dean, Isaac 1 Dias, Irundika H K 1 Gachechiladze, Mariam 1 Hanby, Andrew 1 Hayward, Steven 1 Long, Heather M 1 Mohammed, Fiyaz 1 Molostvov, Guerman 1 Nazarenko, Irina 1 Novitskaya, Vera 1 Paniushkina, Liliia 1 Shaaban, Abeer M 1 Speirs, Valerie 1 Withers, David R 1 van Laere, Steven 1
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Pracoviště
Aston Medical Research Institute Asto... 1 Department of Clinical and Molecular ... 1 Department of Pathology Faculty of Me... 1 Faculty of Medicine Institute for Inf... 1 German Cancer Consortium 69120 Heidel... 1 Institute of Cancer and Genomic Scien... 1 Institute of Immunology and Immunothe... 1 Institute of Medical Sciences Univers... 1 Leeds Institute of Medical Research U... 1 Translational Cancer Research Unit Ce... 1
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Autor
Badr, Nahla 1 Berditchevski, Fedor 1 Danial, Irini 1 Dean, Isaac 1 Dias, Irundika H K 1 Gachechiladze, Mariam 1 Hanby, Andrew 1 Hayward, Steven 1 Long, Heather M 1 Mohammed, Fiyaz 1 Molostvov, Guerman 1 Nazarenko, Irina 1 Novitskaya, Vera 1 Paniushkina, Liliia 1 Shaaban, Abeer M 1 Speirs, Valerie 1 Withers, David R 1 van Laere, Steven 1
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Pracoviště
Aston Medical Research Institute Asto... 1 Department of Clinical and Molecular ... 1 Department of Pathology Faculty of Me... 1 Faculty of Medicine Institute for Inf... 1 German Cancer Consortium 69120 Heidel... 1 Institute of Cancer and Genomic Scien... 1 Institute of Immunology and Immunothe... 1 Institute of Medical Sciences Univers... 1 Leeds Institute of Medical Research U... 1 Translational Cancer Research Unit Ce... 1
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Directory of Open Access Journals od 2012
Free Medical Journals od 2012
Freely Accessible Science Journals od 2012-01-26
Open Access Digital Library od 2012-01-01
Open Access Digital Library od 2012-01-26
Elsevier Open Access Journals od 2012-01-26
PubMed
36867531
DOI
10.1016/j.celrep.2023.112207
Knihovny.cz E-zdroje
The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment of B lymphocytes to BCa tissues is controlled via mechanisms associated with cancer cell-derived extracellular vesicles (CCD-EVs). Gene expression profiling identifies the Liver X receptor (LXR)-dependent transcriptional network as a key pathway that controls both CCD-EVs-induced migration of B cells and accumulation of B cells in BCa tissues. The increased accumulation oxysterol ligands for LXR (i.e., 25-hydroxycholesterol and 27-hydroxycholesterol) in CCD-EVs is regulated by the tetraspanin 6 (Tspan6). Tspan6 stimulates the chemoattractive potential of BCa cells for B cells in an EV- and LXR-dependent manner. These results demonstrate that tetraspanins control intercellular trafficking of oxysterols via CCD-EVs. Furthermore, tetraspanin-dependent changes in the oxysterol composition of CCD-EVs and the LXR signaling axis play a key role in specific changes in the tumor immune microenvironment.
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