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Autor
Agudo, Antonio 1 Ahrens, Wolfgang 1 Barzan, Luigi 1 Bencko, Vladimir 1 Boccia, Stefania 1 Brennan, Paul 1 Canova, Cristina 1 Carreras-Torres, Robert 1 Castellsagué, Xavier 1 Conway, David I 1 Fabianova, Eleonora 1 Foretova, Lenka 1 Gaborieau, Valérie 1 Healy, Claire M 1 Holcátová, Ivana 1 Janout, Vladimir 1 Kjaerheim, Kristina 1 Lagiou, Pagona 1 Lissowska, Jolanta 1 Macfarlane, Tatiana V 1
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Pracoviště
Cancer Epidemiology Research Program ... 1 Cancer Epidemiology Research Program ... 1 Cancer Registry of Norway Oslo Norway 1 Croatian National Cancer Registry Cro... 1 Department of Cancer Epidemiology and... 1 Department of Cancer Epidemiology and... 1 Department of Environmental Medicine ... 1 Department of Epidemiology Institute ... 1 Department of Hygiene Epidemiology an... 1 General Hospital of Pordenone Pordeno... 1 Institute of Carcinogenesis Cancer Re... 1 Institute of Hygiene and Epidemiology... 1 International Agency for Research on ... 1 Leibniz Institute for Prevention Rese... 1 Palacky University Olomouc Czech Repu... 1 Regional Authority of Public Health B... 1 Saint Mary General and Esophageal Sur... 1 School of Medicine and Dentistry Univ... 1 Section of Hygiene Institute of Publi... 1 Section of Hygiene Institute of Publi... 1
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Autor
Agudo, Antonio 1 Ahrens, Wolfgang 1 Barzan, Luigi 1 Bencko, Vladimir 1 Boccia, Stefania 1 Brennan, Paul 1 Canova, Cristina 1 Carreras-Torres, Robert 1 Castellsagué, Xavier 1 Conway, David I 1 Fabianova, Eleonora 1 Foretova, Lenka 1 Gaborieau, Valérie 1 Healy, Claire M 1 Holcátová, Ivana 1 Janout, Vladimir 1 Kjaerheim, Kristina 1 Lagiou, Pagona 1 Lissowska, Jolanta 1 Macfarlane, Tatiana V 1
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Pracoviště
Cancer Epidemiology Research Program ... 1 Cancer Epidemiology Research Program ... 1 Cancer Registry of Norway Oslo Norway 1 Croatian National Cancer Registry Cro... 1 Department of Cancer Epidemiology and... 1 Department of Cancer Epidemiology and... 1 Department of Environmental Medicine ... 1 Department of Epidemiology Institute ... 1 Department of Hygiene Epidemiology an... 1 General Hospital of Pordenone Pordeno... 1 Institute of Carcinogenesis Cancer Re... 1 Institute of Hygiene and Epidemiology... 1 International Agency for Research on ... 1 Leibniz Institute for Prevention Rese... 1 Palacky University Olomouc Czech Repu... 1 Regional Authority of Public Health B... 1 Saint Mary General and Esophageal Sur... 1 School of Medicine and Dentistry Univ... 1 Section of Hygiene Institute of Publi... 1 Section of Hygiene Institute of Publi... 1
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Free Medical Journals od 2011
Nature Open Access od 2011-12-01
PubMed Central od 2011
Europe PubMed Central od 2011
ProQuest Central od 2011-01-01
Open Access Digital Library od 2011-01-01
Open Access Digital Library od 2011-01-01
Health & Medicine (ProQuest) od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources od 2011
PubMed
29540730
DOI
10.1038/s41598-018-22626-w
Knihovny.cz E-zdroje
With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95%CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
- MeSH
- celogenomová asociační studie MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mendelovská randomizace metody MeSH
- nádory hlavy a krku genetika MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- tělesná výška genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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