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Autor
Abedi-Ardekani, Behnoush 1 Anantharaman, Devasena 1 Brennan, Paul 1 Canova, Cristina 1 Durand, Geoffroy 1 Foll, Matthieu 1 Holcatova, Ivana 1 Holmila, Reetta 1 Lagiou, Pagona 1 Le Calvez-Kelm, Florence 1 Levi, José Eduardo 1 McKay, James D 1 Perdomo, Sandra 1 Polesel, Jerry 1 Reis Rosa, Luciana Albina 1 Simonato, Lorenzo 1 Tajara, Eloiza H 1 Vilensky, Marta 1 Wünsch-Filho, Victor 1
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Pracoviště
Centro di Riferimento Oncologico Avia... 1 Charles University of Prague Prague C... 1 Faculdade de Saúde Pública Universida... 1 Instituto Angel Roffo Buenos Aires Ar... 1 Instituto de Medicina Tropical de SP ... 1 International Agency for Research on ... 1 International Agency for Research on ... 1 Laboratory of Public Health and Popul... 1 School of Medicine of São José do Rio... 1 University of Athens Medical School A... 1
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Autor
Abedi-Ardekani, Behnoush 1 Anantharaman, Devasena 1 Brennan, Paul 1 Canova, Cristina 1 Durand, Geoffroy 1 Foll, Matthieu 1 Holcatova, Ivana 1 Holmila, Reetta 1 Lagiou, Pagona 1 Le Calvez-Kelm, Florence 1 Levi, José Eduardo 1 McKay, James D 1 Perdomo, Sandra 1 Polesel, Jerry 1 Reis Rosa, Luciana Albina 1 Simonato, Lorenzo 1 Tajara, Eloiza H 1 Vilensky, Marta 1 Wünsch-Filho, Victor 1
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Pracoviště
Centro di Riferimento Oncologico Avia... 1 Charles University of Prague Prague C... 1 Faculdade de Saúde Pública Universida... 1 Instituto Angel Roffo Buenos Aires Ar... 1 Instituto de Medicina Tropical de SP ... 1 International Agency for Research on ... 1 International Agency for Research on ... 1 Laboratory of Public Health and Popul... 1 School of Medicine of São José do Rio... 1 University of Athens Medical School A... 1
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NLK
Directory of Open Access Journals
od 2006
Free Medical Journals
od 2006
Public Library of Science (PLoS)
od 2006
PubMed Central
od 2006
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od 2006
ProQuest Central
od 2006-12-01
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od 2006-10-01
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od 2006-01-01
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od 2006-01-01
Medline Complete (EBSCOhost)
od 2008-01-01
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od 2006-12-01
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od 2006-12-01
Public Health Database (ProQuest)
od 2006-12-01
ROAD: Directory of Open Access Scholarly Resources
od 2006
PubMed
29377909
DOI
10.1371/journal.pone.0191701
Knihovny.cz E-zdroje
We investigated how somatic changes in HNSCC interact with environmental and host risk factors and whether they influence the risk of HNSCC occurrence and outcome. 180-paired samples diagnosed as HNSCC in two high incidence regions of Europe and South America underwent targeted sequencing (14 genes) and evaluation of copy number alterations (SCNAs). TP53, PIK3CA, NOTCH1, TP63 and CDKN2A were the most frequently mutated genes. Cases were characterized by a low copy number burden with recurrent focal amplification in 11q13.3 and deletion in 15q22. Cases with low SCNAs showed an improved overall survival. We found significant correlations with decreased overall survival between focal amplified regions 4p16, 10q22 and 22q11, and losses in 12p12, 15q14 and 15q22. The mutational landscape in our cases showed an association to both environmental exposures and clinical characteristics. We confirmed that somatic copy number alterations are an important predictor of HNSCC overall survival.
- MeSH
- analýza přežití MeSH
- dospělí MeSH
- incidence MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádory hlavy a krku epidemiologie genetika MeSH
- senioři MeSH
- variabilita počtu kopií segmentů DNA MeSH
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- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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