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Autor
Alcoceba, Miguel 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Blanco, Gonzalo 1 Butrym, Aleksandra 1 Cabrera-Serrano, Antonio José 1 Campa, Daniele 1 Canzian, Federico 1 Casabonne, Delphine 1 Cerhan, James R 1 Chen-Liang, Tzu 1 Clay-Gilmour, Alyssa 1 Dierssen-Sotos, Trinidad 1 Espinet, Blanca 1 Försti, Asta 1 García-Martín, Paloma 1 García-Álvarez, María 1 Giaccherini, Matteo 1 Gámez, Irene 1 Hemminki, Kari 1
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Pracoviště
CIBER Epidemiología y Salud Pública 2... 1 Cancer Prevention and Control Program... 1 Catalan Institute of Oncology Bellvit... 1 CeMM Research Center for Molecular Me... 1 Centre for Individualised Infection M... 1 Consortium for Biomedical Research in... 1 Department for Immunology and Metabol... 1 Department of Biochemistry and Molecu... 1 Department of Biology University of P... 1 Department of Cancer Prevention and T... 1 Department of Clinical Sciences Facul... 1 Department of Epidemiology and Biosta... 1 Department of Hematology Experimental... 1 Department of Hematology University H... 1 Department of Internal Medicine and R... 1 Department of Leukemia The University... 1 Department of Medical and Surgical Sc... 1 Department of Nursing Universitat de ... 1 Department of Quantitative Health Sci... 1 Division of Cancer Epidemiology Germa... 1
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Autor
Alcoceba, Miguel 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Blanco, Gonzalo 1 Butrym, Aleksandra 1 Cabrera-Serrano, Antonio José 1 Campa, Daniele 1 Canzian, Federico 1 Casabonne, Delphine 1 Cerhan, James R 1 Chen-Liang, Tzu 1 Clay-Gilmour, Alyssa 1 Dierssen-Sotos, Trinidad 1 Espinet, Blanca 1 Försti, Asta 1 García-Martín, Paloma 1 García-Álvarez, María 1 Giaccherini, Matteo 1 Gámez, Irene 1 Hemminki, Kari 1
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Pracoviště
CIBER Epidemiología y Salud Pública 2... 1 Cancer Prevention and Control Program... 1 Catalan Institute of Oncology Bellvit... 1 CeMM Research Center for Molecular Me... 1 Centre for Individualised Infection M... 1 Consortium for Biomedical Research in... 1 Department for Immunology and Metabol... 1 Department of Biochemistry and Molecu... 1 Department of Biology University of P... 1 Department of Cancer Prevention and T... 1 Department of Clinical Sciences Facul... 1 Department of Epidemiology and Biosta... 1 Department of Hematology Experimental... 1 Department of Hematology University H... 1 Department of Internal Medicine and R... 1 Department of Leukemia The University... 1 Department of Medical and Surgical Sc... 1 Department of Nursing Universitat de ... 1 Department of Quantitative Health Sci... 1 Division of Cancer Epidemiology Germa... 1
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- Cabrera-Serrano, Antonio José
- Sánchez-Maldonado, José Manuel
- Ter Horst, Rob
- Macauda, Angelica
- García-Martín, Paloma
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Benavente, Yolanda
Autor Benavente, Yolanda ORCID Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), University of Barcelona, 08908 Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Landi, Stefano
- Clay-Gilmour, Alyssa
- Niazi, Yasmeen
- Espinet, Blanca
Free Medical Journals od 2000
Freely Accessible Science Journals od 2000
PubMed Central od 2007
Europe PubMed Central od 2007
ProQuest Central od 2000-03-01
Open Access Digital Library od 2000-01-01
Open Access Digital Library od 2007-01-01
Health & Medicine (ProQuest) od 2000-03-01
ROAD: Directory of Open Access Scholarly Resources od 2000
PubMed
37175717
DOI
10.3390/ijms24098005
Knihovny.cz E-zdroje
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for CLL could influence overall survival (OS) and disease progression, defined as time to first treatment (TTFT) in a cohort of 1039 CLL cases ascertained through the CRuCIAL consortium. Although this is the largest study assessing the effect of GWAS-identified susceptibility variants for CLL on OS, we only found a weak association of ten single nucleotide polymorphisms (SNPs) with OS (p < 0.05) that did not remain significant after correction for multiple testing. In line with these results, polygenic risk scores (PRSs) built with these SNPs in the CRuCIAL cohort showed a modest association with OS and a low capacity to predict patient survival, with an area under the receiver operating characteristic curve (AUROC) of 0.57. Similarly, seven SNPs were associated with TTFT (p < 0.05); however, these did not reach the multiple testing significance threshold, and the meta-analysis with previous published data did not confirm any of the associations. As expected, PRSs built with these SNPs showed reduced accuracy in prediction of disease progression (AUROC = 0.62). These results suggest that susceptibility variants for CLL do not impact overall survival and disease progression in CLL patients.
- MeSH
- celogenomová asociační studie MeSH
- chronická lymfatická leukemie * genetika MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- progrese nemoci MeSH
- rizikové faktory MeSH
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- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
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