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Autor
Arat, Mutlu 1 Basak, Grzegorz W 1 Benner, Axel 1 Corral, Lucia López 1 Dreger, Peter 1 Itäla-Remes, Maija 1 Karas, Michal 1 Koenecke, Christian 1 Kordelas, Lambros 1 Luft, Thomas 1 Metafuni, Elisabetta 1 Moiseev, Ivan 1 Ozcelik, Tulay 1 Peczynski, Christophe 1 Penack, Olaf 1 Peric, Zinaida 1 Raida, Ludek 1 Sandmaier, Brenda M 1 Schaap, Nicolaas P M 1 Schoemans, Hélène 1
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Pracoviště
1st Pavlov State Medical University o... 1 Department for Haematology Hospital C... 1 Department for Haematology Oncology a... 1 Department of Haematology Sorbonne Un... 1 Department of Hematology Oncology and... 1 Department of Hematology Radboudumc N... 1 Department of Hematology University H... 1 Department of Hematology University o... 1 Dept of Hematology and Stem Cell Tran... 1 EBMT Transplant Complications Working... 1 EBMT Transplant Complications Working... 1 Florence Nightingale Hospital Hematop... 1 German Cancer Research Centre Heidelb... 1 Hematology Hemostasis Oncology and St... 1 Hospital Dept of Hematology Oncology ... 1 Istituto di Ematologia Universita Cat... 1 Medicine 5 University Hospital Heidel... 1 Olomouc University Social Health Inst... 1 Turku University Hospital FI Turku Fi... 1 University of Washington Seattle Wash... 1
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Autor
Arat, Mutlu 1 Basak, Grzegorz W 1 Benner, Axel 1 Corral, Lucia López 1 Dreger, Peter 1 Itäla-Remes, Maija 1 Karas, Michal 1 Koenecke, Christian 1 Kordelas, Lambros 1 Luft, Thomas 1 Metafuni, Elisabetta 1 Moiseev, Ivan 1 Ozcelik, Tulay 1 Peczynski, Christophe 1 Penack, Olaf 1 Peric, Zinaida 1 Raida, Ludek 1 Sandmaier, Brenda M 1 Schaap, Nicolaas P M 1 Schoemans, Hélène 1
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Pracoviště
1st Pavlov State Medical University o... 1 Department for Haematology Hospital C... 1 Department for Haematology Oncology a... 1 Department of Haematology Sorbonne Un... 1 Department of Hematology Oncology and... 1 Department of Hematology Radboudumc N... 1 Department of Hematology University H... 1 Department of Hematology University o... 1 Dept of Hematology and Stem Cell Tran... 1 EBMT Transplant Complications Working... 1 EBMT Transplant Complications Working... 1 Florence Nightingale Hospital Hematop... 1 German Cancer Research Centre Heidelb... 1 Hematology Hemostasis Oncology and St... 1 Hospital Dept of Hematology Oncology ... 1 Istituto di Ematologia Universita Cat... 1 Medicine 5 University Hospital Heidel... 1 Olomouc University Social Health Inst... 1 Turku University Hospital FI Turku Fi... 1 University of Washington Seattle Wash... 1
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NLK
BioMedCentral Open Access
od 2013
Directory of Open Access Journals
od 2013
Free Medical Journals
od 2013
PubMed Central
od 2013
Europe PubMed Central
od 2013
ProQuest Central
od 2013-05-01
Open Access Digital Library
od 2013-01-01
Open Access Digital Library
od 2013-01-01
Health & Medicine (ProQuest)
od 2013-05-01
ROAD: Directory of Open Access Scholarly Resources
od 2013
PubMed
38199608
DOI
10.1136/jitc-2023-007635
Knihovny.cz E-zdroje
BACKGROUND: We previously reported that the "Endothelial Activation and Stress Index" (EASIX; ((creatinine×lactate dehydrogenase)÷thrombocytes)) measured before start of conditioning predicts mortality after allogeneic hematopoietic stem cell transplantation (alloSCT) when used as continuous score. For broad clinical implementation, a prospectively validated EASIX-pre cut-off is needed that defines a high-risk cohort and is easy to use. METHOD: In the current study, we first performed a retrospective cohort analysis in n=2022 alloSCT recipients and identified an optimal cut-off for predicting non-relapse mortality (NRM) as EASIX-pre=3. For cut-off validation, we conducted a multicenter prospective study with inclusion of n=317 first alloSCTs from peripheral blood stem cell in adult patients with acute leukemia, lymphoma or myelodysplastic syndrome/myeloproliferative neoplasms in the European Society for Blood and Marrow Transplantation network. RESULTS: Twenty-three % (n=74) of alloSCT recipients had EASIX-pre ≥3 taken before conditioning. NRM at 2 years was 31.1% in the high EASIX group versus 11.5% in the low EASIX group (p<0.001). Patients with high EASIX-pre also had worse 2 years overall survival (51.6% vs 70.9%; p=0.002). We were able to validate the cut-off and found that EASIX ≥3 was associated with more than twofold increased risk for NRM in multivariate analysis (HR=2.18, 95% CI 1.2 to 3.94; p=0.01). No statistically significant difference could be observed for the incidence of relapse. CONCLUSIONS: The results of this study provide a prospectively validated standard laboratory biomarker index to estimate the transplant-related mortality risk after alloSCT. EASIX ≥3 taken before conditioning identifies a population of alloSCT recipients who have a more than twofold increased risk of treatment-related mortality.
- MeSH
- dospělí MeSH
- kreatinin MeSH
- lidé MeSH
- prospektivní studie MeSH
- retrospektivní studie MeSH
- transplantace hematopoetických kmenových buněk * škodlivé účinky MeSH
- trombocyty MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
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