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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Arslan, Alan A 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Birmann, Brenda M 1 Bofetta, Paulo 1 Bracci, Paige M 1 Brennan, Paul 1 Brooks-Wilson, Angela 1 Brown, Elizabeth E 1 Camp, Nicola J 1 Carrington, Mary 1 Cerhan, James R 1 Chanock, Stephen J 1 Clavel, Jacqueline 1 Cocco, Pierluigi 1 Conde, Lucia 1 Cox, David G 1
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Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 Braun School of Public Health and Com... 1 Cancer Control Research British Colum... 1 Cancer Epidemiology Unit University o... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Research Center of Lyon INSERM... 1 Cancer and Inflammation Program Leido... 1 Center of Oncological Prevention Piem... 1 Centre for Big Data Research in Healt... 1 Centre for Chronic Immunodeficiency U... 1 Channing Division of Network Medicine... 1 Department of Biomedical Physiology a... 1 Department of Biomedical Science Univ... 1 Department of Cancer Epidemiology and... 1 Department of Epidemiology Harvard T ... 1 Department of Epidemiology Research D... 1 Department of Epidemiology Research D... 1 Department of Epidemiology School of ... 1 Department of Epidemiology and Biosta... 1
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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Arslan, Alan A 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Birmann, Brenda M 1 Bofetta, Paulo 1 Bracci, Paige M 1 Brennan, Paul 1 Brooks-Wilson, Angela 1 Brown, Elizabeth E 1 Camp, Nicola J 1 Carrington, Mary 1 Cerhan, James R 1 Chanock, Stephen J 1 Clavel, Jacqueline 1 Cocco, Pierluigi 1 Conde, Lucia 1 Cox, David G 1
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Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 Braun School of Public Health and Com... 1 Cancer Control Research British Colum... 1 Cancer Epidemiology Unit University o... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Research Center of Lyon INSERM... 1 Cancer and Inflammation Program Leido... 1 Center of Oncological Prevention Piem... 1 Centre for Big Data Research in Healt... 1 Centre for Chronic Immunodeficiency U... 1 Channing Division of Network Medicine... 1 Department of Biomedical Physiology a... 1 Department of Biomedical Science Univ... 1 Department of Cancer Epidemiology and... 1 Department of Epidemiology Harvard T ... 1 Department of Epidemiology Research D... 1 Department of Epidemiology Research D... 1 Department of Epidemiology School of ... 1 Department of Epidemiology and Biosta... 1
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Freely Accessible Science Journals od 1941 do Před 1 rokem
Open Access Digital Library od 1941-01-01
Open Access Digital Library od 1941-01-01
PubMed
29735552
DOI
10.1158/0008-5472.can-17-2900
Knihovny.cz E-zdroje
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL = 1.31, 95% CI = 1.06-1.60; OR MZL = 1.45, 95% CI = 1.12-1.89) and class II HLA-DRB1 locus (OR DLBCL = 2.10, 95% CI = 1.24-3.55; OR MZL = 2.10, 95% CI = 0.99-4.45). Increased FL risk was observed with the overall increase in number of homozygous HLA class II loci (P trend < 0.0001, FDR = 0.0005). These results support a role for HLA zygosity in NHL etiology and suggests that distinct immune pathways may underly the etiology of the different NHL subtypes.Significance: HLA gene diversity reduces risk for non-Hodgkin lymphoma. Cancer Res; 78(14); 4086-96. ©2018 AACR.
- MeSH
- celogenomová asociační studie metody MeSH
- genetická heterogenita MeSH
- heterozygot MeSH
- histokompatibilita - antigeny třídy I genetika MeSH
- histokompatibilita - antigeny třídy II genetika MeSH
- lidé MeSH
- nehodgkinský lymfom genetika MeSH
- prospektivní studie MeSH
- studie případů a kontrol MeSH
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- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
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