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Autor
Bartek, Tomáš 1 Coufalová, Pavla 1 Cwiková, Lucie 1 Dobiáš, Radim 1 Havlíček, Vladimír 1 Janíčková, Ivana 1 Jaworská, Pavla 1 Kozel, Radovan 1 Krejčí, Eva 1 Káňová, Marcela 1 Lysková, Pavlína 1 Martinek, Jan 1 Navrátil, Milan 1 Raška, Milan 1 Skopelidou, Valeria 1 Stevens, David A 1 Strakoš, Jan 1 Ulmann, Vít 1 Višňovská, Denisa 1 Vrba, Zbyněk 1
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Pracoviště
California Institute for Medical Rese... 1 Department of Analytical Chemistry Fa... 1 Department of Anesthesiology and Inte... 1 Department of Bacteriology and Mycolo... 1 Department of Biology and Ecology Fac... 1 Department of Clinical Biochemistry A... 1 Department of Epidemiology and Public... 1 Department of Hemato oncology Univers... 1 Department of Immunology Faculty of M... 1 Department of Immunology Public Healt... 1 Department of Intensive Medicine Emer... 1 Department of Lung Disease and Tuberc... 1 Department of Medical Microbiology Pr... 1 Department of Microbiology Faculty of... 1 Department of Pneumology and Phthisio... 1 Division of Infectious Diseases and G... 1 Institute of Laboratory Medicine Facu... 1 Institute of Microbiology of the Czec... 1 Institute of Physiology and Pathophys... 1 Lung Department Krnov Combined Medica... 1
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Autor
Bartek, Tomáš 1 Coufalová, Pavla 1 Cwiková, Lucie 1 Dobiáš, Radim 1 Havlíček, Vladimír 1 Janíčková, Ivana 1 Jaworská, Pavla 1 Kozel, Radovan 1 Krejčí, Eva 1 Káňová, Marcela 1 Lysková, Pavlína 1 Martinek, Jan 1 Navrátil, Milan 1 Raška, Milan 1 Skopelidou, Valeria 1 Stevens, David A 1 Strakoš, Jan 1 Ulmann, Vít 1 Višňovská, Denisa 1 Vrba, Zbyněk 1
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Pracoviště
California Institute for Medical Rese... 1 Department of Analytical Chemistry Fa... 1 Department of Anesthesiology and Inte... 1 Department of Bacteriology and Mycolo... 1 Department of Biology and Ecology Fac... 1 Department of Clinical Biochemistry A... 1 Department of Epidemiology and Public... 1 Department of Hemato oncology Univers... 1 Department of Immunology Faculty of M... 1 Department of Immunology Public Healt... 1 Department of Intensive Medicine Emer... 1 Department of Lung Disease and Tuberc... 1 Department of Medical Microbiology Pr... 1 Department of Microbiology Faculty of... 1 Department of Pneumology and Phthisio... 1 Division of Infectious Diseases and G... 1 Institute of Laboratory Medicine Facu... 1 Institute of Microbiology of the Czec... 1 Institute of Physiology and Pathophys... 1 Lung Department Krnov Combined Medica... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Dobiáš, Radim
- Jaworská, Pavla
- Skopelidou, Valeria
- Strakoš, Jan
- Višňovská, Denisa
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Káňová, Marcela
Autor Káňová, Marcela ORCID Department of Anesthesiology and Intensive Care Medicine, University Hospital Ostrava, 70800 Ostrava, Czech Republic Institute of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, 71000 Ostrava, Czech Republic Department of Intensive Medicine, Emergency Medicine and Forensic Studies, University of Ostrava, 71000 Ostrava, Czech Republic
- Škríba, Anton
- Lysková, Pavlína
- Bartek, Tomáš
- Janíčková, Ivana
PubMed Central od 2015
Europe PubMed Central od 2015
ProQuest Central od 2015-06-01
Open Access Digital Library od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources od 2015
PubMed
36422015
DOI
10.3390/jof8111194
Knihovny.cz E-zdroje
The multiple forms of pulmonary aspergillosis caused by Aspergillus species are the most common respiratory mycoses. Although invasive, the analysis of diagnostic biomarkers in bronchoalveolar lavage fluid (BALF) is a clinical standard for diagnosing these conditions. The BALF samples from 22 patients with proven or probable aspergillosis were assayed for human pentraxin 3 (Ptx3), fungal ferricrocin (Fc), and triacetylfusarinine C (TafC) in a retrospective study. The infected group included patients with invasive pulmonary aspergillosis (IPA) and chronic aspergillosis (CPA). The BALF data were compared to a control cohort of 67 patients with invasive pulmonary mucormycosis (IPM), non-Aspergillus colonization, or bacterial infections. The median Ptx3 concentrations in patients with and without aspergillosis were 4545.5 and 242.0 pg/mL, respectively (95% CI, p < 0.05). The optimum Ptx3 cutoff for IPA was 2545 pg/mL, giving a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 100, 98, 95, and 100%, respectively. The median Ptx3 concentration for IPM was high at 4326 pg/mL. Pentraxin 3 assay alone can distinguish IPA from CPA and invasive fungal disease from colonization. Combining Ptx3 and TafC assays enabled the diagnostic discrimination of IPM and IPA, giving a specificity and PPV of 100%.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.