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Autor
Anckaert, Jasper 1 Avila Cobos, Francisco 1 Bracke, Ken R 1 Brochez, Lieve 1 Brusselle, Guy 1 Derveaux, Thierry 1 Geerts, Anja 1 Hemelsoet, Dimitri 1 Hindryckx, Pieter 1 Hulstaert, Eva 1 Jacques, Peggy 1 Karg, Sebastian 1 Kautzky-Willers, Alexandra 1 Koster, Jan 1 Kuersten, Scott 1 Lefever, Steve 1 Leutner, Michael 1 Maes, Tania 1 Malfait, Thomas 1 Mestdagh, Pieter 1
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Pracoviště
Austrian Institute of Technology Cent... 1 Center for Medical Genetics Departmen... 1 Central European Institute of Technol... 1 Department of Dermatology Ghent Unive... 1 Department of Gastroenterology Ghent ... 1 Department of Internal Medicine 3 Cli... 1 Department of Neurology Ghent Univers... 1 Department of Obstetrics Women's Clin... 1 Department of Oncogenomics Amsterdam ... 1 Department of Ophthalmology Ghent Uni... 1 Department of Pathology University Ho... 1 Department of Reproductive Medicine G... 1 Department of Respiratory Medicine Gh... 1 Department of Rheumatology Ghent Univ... 1 Helmholtz Zentrum München German Rese... 1 Illumina San Diego CA USA 1 Masaryk Memorial Cancer Institute Dep... 1 OncoRNALab Cancer Research Institute ... 1 University of Texas Health Science Ce... 1 VIB Inflammation Research Center Ghen... 1
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Autor
Anckaert, Jasper 1 Avila Cobos, Francisco 1 Bracke, Ken R 1 Brochez, Lieve 1 Brusselle, Guy 1 Derveaux, Thierry 1 Geerts, Anja 1 Hemelsoet, Dimitri 1 Hindryckx, Pieter 1 Hulstaert, Eva 1 Jacques, Peggy 1 Karg, Sebastian 1 Kautzky-Willers, Alexandra 1 Koster, Jan 1 Kuersten, Scott 1 Lefever, Steve 1 Leutner, Michael 1 Maes, Tania 1 Malfait, Thomas 1 Mestdagh, Pieter 1
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Pracoviště
Austrian Institute of Technology Cent... 1 Center for Medical Genetics Departmen... 1 Central European Institute of Technol... 1 Department of Dermatology Ghent Unive... 1 Department of Gastroenterology Ghent ... 1 Department of Internal Medicine 3 Cli... 1 Department of Neurology Ghent Univers... 1 Department of Obstetrics Women's Clin... 1 Department of Oncogenomics Amsterdam ... 1 Department of Ophthalmology Ghent Uni... 1 Department of Pathology University Ho... 1 Department of Reproductive Medicine G... 1 Department of Respiratory Medicine Gh... 1 Department of Rheumatology Ghent Univ... 1 Helmholtz Zentrum München German Rese... 1 Illumina San Diego CA USA 1 Masaryk Memorial Cancer Institute Dep... 1 OncoRNALab Cancer Research Institute ... 1 University of Texas Health Science Ce... 1 VIB Inflammation Research Center Ghen... 1
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Hulstaert, Eva
Autor Hulstaert, Eva Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium OncoRNALab, Cancer Research Institute Ghent (CRIG), Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium Department of Dermatology, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium
- Morlion, Annelien
- Avila Cobos, Francisco
- Verniers, Kimberly
- Nuytens, Justine
- Vanden Eynde, Eveline
- Yigit, Nurten
- Anckaert, Jasper
- Geerts, Anja
- Hindryckx, Pieter
Directory of Open Access Journals od 2012
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Open Access Digital Library od 2012-01-01
Elsevier Open Access Journals od 2012-01-26
PubMed
33378673
DOI
10.1016/j.celrep.2020.108552
Knihovny.cz E-zdroje
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids. By means of synthetic spike-in controls, we compare RNA content across biofluids, revealing a 10,000-fold difference in concentration. The circular RNA fraction is increased in most biofluids compared to tissues. Each biofluid transcriptome is enriched for RNA molecules derived from specific tissues and cell types. Our atlas enables an informed selection of the most relevant biofluid to monitor particular diseases. To verify the biomarker potential in these biofluids, four validation cohorts representing a broad spectrum of diseases were profiled, revealing numerous differential RNAs between case and control subjects. Spike-normalized data are publicly available in the R2 web portal for further exploration.
- MeSH
- biologické markery * MeSH
- kohortové studie MeSH
- lidé MeSH
- RNA genetika metabolismus MeSH
- sekvenční analýza RNA metody MeSH
- stanovení celkové genové exprese metody MeSH
- tělesné tekutiny metabolismus MeSH
- transkriptom * MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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