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Autor
Amato, Maria Pia 1 Chandraratna, Dhia 1 Clanet, Michel 1 Comi, Giancarlo 1 Derfuss, Tobias 1 Fazekas, Franz 1 Gold, Ralf 1 Hartung, Hans Peter 1 Havrdova, Eva 1 Hemmer, Bernhard 1 Kappos, Ludwig 1 Liblau, Roland 1 Lubetzki, Catherine 1 Marcus, Elena 1 Miller, David H 1 Montalban, Xavier 1 Olsson, Tomas 1 Otero-Romero, Susana 1 Pilling, Steve 1 Selmaj, Krysztof 1
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Pracoviště
Biostatistics Unit University of Geno... 1 Centre for Outcomes Research and Effe... 1 Clinical Neuroimmunology Unit and MS ... 1 Department of Brain Repair and Rehabi... 1 Department of Neurology Danish Multip... 1 Department of Neurology Focus Program... 1 Department of Neurology Klinikum Rech... 1 Department of Neurology Medical Unive... 1 Department of Neurology Medical Unive... 1 Department of Neurology Neuroimmunolo... 1 Department of Neurology Neuroimmunolo... 1 Department of Neurology Ruhr Universi... 1 Department of Neurology Toulouse Univ... 1 Department of Neurology University of... 1 Department of Neurology and Center of... 1 Department of Neurosciences Psycholog... 1 Departments of Neurology and Biomedic... 1 European Multiple Sclerosis Platform ... 1 INSERM UMR U1043 CNRS U5282 Universit... 1 Multiple Sclerosis Center Department ... 1
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Autor
Amato, Maria Pia 1 Chandraratna, Dhia 1 Clanet, Michel 1 Comi, Giancarlo 1 Derfuss, Tobias 1 Fazekas, Franz 1 Gold, Ralf 1 Hartung, Hans Peter 1 Havrdova, Eva 1 Hemmer, Bernhard 1 Kappos, Ludwig 1 Liblau, Roland 1 Lubetzki, Catherine 1 Marcus, Elena 1 Miller, David H 1 Montalban, Xavier 1 Olsson, Tomas 1 Otero-Romero, Susana 1 Pilling, Steve 1 Selmaj, Krysztof 1
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Pracoviště
Biostatistics Unit University of Geno... 1 Centre for Outcomes Research and Effe... 1 Clinical Neuroimmunology Unit and MS ... 1 Department of Brain Repair and Rehabi... 1 Department of Neurology Danish Multip... 1 Department of Neurology Focus Program... 1 Department of Neurology Klinikum Rech... 1 Department of Neurology Medical Unive... 1 Department of Neurology Medical Unive... 1 Department of Neurology Neuroimmunolo... 1 Department of Neurology Neuroimmunolo... 1 Department of Neurology Ruhr Universi... 1 Department of Neurology Toulouse Univ... 1 Department of Neurology University of... 1 Department of Neurology and Center of... 1 Department of Neurosciences Psycholog... 1 Departments of Neurology and Biomedic... 1 European Multiple Sclerosis Platform ... 1 INSERM UMR U1043 CNRS U5282 Universit... 1 Multiple Sclerosis Center Department ... 1
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PubMed
29353550
DOI
10.1177/1352458517751049
Knihovny.cz E-zdroje
BACKGROUND: Multiple sclerosis (MS) is a complex disease with new drugs becoming available in the past years. There is a need for a reference tool compiling current data to aid professionals in treatment decisions. OBJECTIVES: To develop an evidence-based clinical practice guideline for the pharmacological treatment of people with MS. METHODS: This guideline has been developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology and following the updated EAN recommendations. Clinical questions were formulated in Patients-Intervention-Comparator-Outcome (PICO) format and outcomes were prioritized. The quality of evidence was rated into four categories according to the risk of bias. The recommendations with assigned strength (strong and weak) were formulated based on the quality of evidence and the risk-benefit balance. Consensus between the panelists was reached by use of the modified nominal group technique. RESULTS: A total of 10 questions were agreed, encompassing treatment efficacy, response criteria, strategies to address suboptimal response and safety concerns and treatment strategies in MS and pregnancy. The guideline takes into account all disease-modifying drugs approved by the European Medicine Agency (EMA) at the time of publication. A total of 21 recommendations were agreed by the guideline working group after three rounds of consensus. CONCLUSION: The present guideline will enable homogeneity of treatment decisions across Europe.
- MeSH
- imunologické faktory aplikace a dávkování MeSH
- imunomodulace * MeSH
- konsensus * MeSH
- lidé MeSH
- medicína založená na důkazech normy MeSH
- roztroušená skleróza farmakoterapie MeSH
- směrnice pro lékařskou praxi jako téma normy MeSH
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- lidé MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
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