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Autor
Akoua-Koffi, Chantal 1 Bergl, Richard A 1 Boesch, Christophe 1 Calvignac-Spencer, Sébastien 1 Ehlers, Bernhard 1 Fruth, Barbara 1 Gillespie, Thomas R 1 Gray, Maryke 1 Hohmann, Gottfried 1 Hoppe, Eileen 1 Karhemere, Stomy 1 Leendertz, Fabian H 1 Madinda, Nadège F 1 Mugisha, Lawrence 1 Muyembe, Jean-Jacques 1 Pauly, Maude 1 Petrzelkova, Klara J 1 Robbins, Martha 1 Schubert, Grit 1 Todd, Angelique 1
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Pracoviště
Centre de Recherche pour le Développe... 1 College of Veterinary Medicine Animal... 1 Department of Environmental Sciences ... 1 Department of Primatology Max Planck ... 1 Department of Primatology Max Planck ... 1 Division 12 Measles Mumps Rubella and... 1 Division 12 Measles Mumps Rubella and... 1 Division of Neurobiology Ludwig Maxim... 1 Epidemiology of highly pathogenic mic... 1 Epidemiology of highly pathogenic mic... 1 Institut National de Recherche Bioméd... 1 Institute of Biology University of Ne... 1 Institute of Vertebrate Biology Acade... 1 International Gorilla Conservation Pr... 1 North Carolina Zoological Park Ashebo... 1 World Wildlife Foundation Dzanga Sang... 1
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Autor
Akoua-Koffi, Chantal 1 Bergl, Richard A 1 Boesch, Christophe 1 Calvignac-Spencer, Sébastien 1 Ehlers, Bernhard 1 Fruth, Barbara 1 Gillespie, Thomas R 1 Gray, Maryke 1 Hohmann, Gottfried 1 Hoppe, Eileen 1 Karhemere, Stomy 1 Leendertz, Fabian H 1 Madinda, Nadège F 1 Mugisha, Lawrence 1 Muyembe, Jean-Jacques 1 Pauly, Maude 1 Petrzelkova, Klara J 1 Robbins, Martha 1 Schubert, Grit 1 Todd, Angelique 1
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Pracoviště
Centre de Recherche pour le Développe... 1 College of Veterinary Medicine Animal... 1 Department of Environmental Sciences ... 1 Department of Primatology Max Planck ... 1 Department of Primatology Max Planck ... 1 Division 12 Measles Mumps Rubella and... 1 Division 12 Measles Mumps Rubella and... 1 Division of Neurobiology Ludwig Maxim... 1 Epidemiology of highly pathogenic mic... 1 Epidemiology of highly pathogenic mic... 1 Institut National de Recherche Bioméd... 1 Institute of Biology University of Ne... 1 Institute of Vertebrate Biology Acade... 1 International Gorilla Conservation Pr... 1 North Carolina Zoological Park Ashebo... 1 World Wildlife Foundation Dzanga Sang... 1
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PubMed Central od 2008
Open Access Digital Library od 1983-12-01
Open Access Digital Library od 1983-12-01
Oxford Journals Open Access Collection od 1996-01-01
Oxford Journals Open Access Collection od 2002
ROAD: Directory of Open Access Scholarly Resources od 1983
PubMed
25862141
DOI
10.1093/molbev/msv090
Knihovny.cz E-zdroje
Human adenoviruses (HAdV; species HAdV-A to -G) are highly prevalent in the human population, and represent an important cause of morbidity and, to a lesser extent, mortality. Recent studies have identified close relatives of these viruses in African great apes, suggesting that some HAdV may be of zoonotic origin. We analyzed more than 800 fecal samples from wild African great apes and humans to further investigate the evolutionary history and zoonotic potential of hominine HAdV. HAdV-B and -E were frequently detected in wild gorillas (55%) and chimpanzees (25%), respectively. Bayesian ancestral host reconstruction under discrete diffusion models supported a gorilla and chimpanzee origin for these viral species. Host switches were relatively rare along HAdV evolution, with about ten events recorded in 4.5 My. Despite presumably rare direct contact between sympatric populations of the two species, transmission events from gorillas to chimpanzees were observed, suggesting that habitat and dietary overlap may lead to fecal-oral cross-hominine transmission of HAdV. Finally, we determined that two independent HAdV-B transmission events to humans occurred more than 100,000 years ago. We conclude that HAdV-B circulating in humans are of zoonotic origin and have probably affected global human health for most of our species lifetime.
- MeSH
- Adenoviridae * genetika patogenita MeSH
- adenovirové infekce * genetika přenos MeSH
- druhová specificita MeSH
- Hominidae virologie MeSH
- lidé MeSH
- molekulární evoluce * MeSH
- zoonózy genetika přenos MeSH
- zvířata MeSH
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- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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