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Adaptive Immunity Group Central Europ... 1 Center of Life Sciences Skolkovo Inst... 1 Division of Infection and Immunity Ca... 1 Faculty of Bioengineering and Bioinfo... 1 Genomics of Adaptive Immunity Departm... 1 Institute of Translational Medicine C... 1 Systems Immunity Research Institute C... 1
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Adaptive Immunity Group Central Europ... 1 Center of Life Sciences Skolkovo Inst... 1 Division of Infection and Immunity Ca... 1 Faculty of Bioengineering and Bioinfo... 1 Genomics of Adaptive Immunity Departm... 1 Institute of Translational Medicine C... 1 Systems Immunity Research Institute C... 1
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- Kasatskaya, Sofya A
- Ladell, Kristin
- Egorov, Evgeniy S
- Miners, Kelly L
- Davydov, Alexey N
- Metsger, Maria
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Staroverov, Dmitry B
Autor Staroverov, Dmitry B Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russian Federation
- Matveyshina, Elena K
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Shagina, Irina A
Autor Shagina, Irina A Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russian Federation
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Mamedov, Ilgar Z
Autor Mamedov, Ilgar Z Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russian Federation
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PubMed
33289628
DOI
10.7554/elife.57063
Knihovny.cz E-zdroje
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs). To address this issue, we used a high-throughput approach to profile the αβ TCR repertoires of human naive and effector/memory CD4+ T-cell subsets, irrespective of antigen specificity. Highly conserved physicochemical and recombinatorial features were encoded on a subset-specific basis in the effector/memory compartment. Clonal tracking further identified forbidden and permitted transition pathways, mapping effector/memory subsets related by interconversion or ontogeny. Public sequences were largely confined to particular effector/memory subsets, including regulatory T cells (Tregs), which also displayed hardwired repertoire features in the naive compartment. Accordingly, these cumulative repertoire portraits establish a link between clonotype fate decisions in the complex world of CD4+ T cells and the intrinsic properties of somatically rearranged TCRs.
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