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Autor
Baliakas, Panagiotis 2 Baran-Marszak, Fanny 2 Benito, Rocío 2 Bonfiglio, Silvia 2 Bosch, Francesc 2 Brieghel, Christian 2 Bullinger, Lars 2 Bödör, Csaba 2 Calasanz, María José 2 Campo, Elias 2 Catherwood, Mark 2 Cuneo, Antonio 2 Davis, Zadie 2 Delgado, Julio 2 Espinet, Blanca 2 Foroughi-Asl, Hassan 2 Fésüs, Viktória 2 Gaidano, Gianluca 2 Ghia, Paolo 2 Gogia, Ajay 2
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Pracoviště
All India Institute of Medical Scienc... 2 Cancer Genomics School for Cancer Sci... 2 Cancer Research Center CSIC Universit... 2 Central European Institute of Technol... 2 Central Hospital of Southern Pest Nat... 2 Centre for Research and Technology He... 2 Centro de Investigación Biomédica en ... 2 Clinical Epidemiology Division Depart... 2 Clinical Genetics Karolinska Universi... 2 Department of Hematology Hospital Uni... 2 Department of Hematology INCLIVA Rese... 2 Department of Hematology Oncology and... 2 Department of Hematology Rigshospital... 2 Department of Hematology University H... 2 Department of Immunology Genetics and... 2 Department of Internal Medicine Hemat... 2 Department of Mathematics University ... 2 Department of Molecular Medicine and ... 2 Department of Oncology and Haematolog... 2 Division of Hematology Department of ... 2
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Autor
Baliakas, Panagiotis 2 Baran-Marszak, Fanny 2 Benito, Rocío 2 Bonfiglio, Silvia 2 Bosch, Francesc 2 Brieghel, Christian 2 Bullinger, Lars 2 Bödör, Csaba 2 Calasanz, María José 2 Campo, Elias 2 Catherwood, Mark 2 Cuneo, Antonio 2 Davis, Zadie 2 Delgado, Julio 2 Espinet, Blanca 2 Foroughi-Asl, Hassan 2 Fésüs, Viktória 2 Gaidano, Gianluca 2 Ghia, Paolo 2 Gogia, Ajay 2
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Pracoviště
All India Institute of Medical Scienc... 2 Cancer Genomics School for Cancer Sci... 2 Cancer Research Center CSIC Universit... 2 Central European Institute of Technol... 2 Central Hospital of Southern Pest Nat... 2 Centre for Research and Technology He... 2 Centro de Investigación Biomédica en ... 2 Clinical Epidemiology Division Depart... 2 Clinical Genetics Karolinska Universi... 2 Department of Hematology Hospital Uni... 2 Department of Hematology INCLIVA Rese... 2 Department of Hematology Oncology and... 2 Department of Hematology Rigshospital... 2 Department of Hematology University H... 2 Department of Immunology Genetics and... 2 Department of Internal Medicine Hemat... 2 Department of Mathematics University ... 2 Department of Molecular Medicine and ... 2 Department of Oncology and Haematolog... 2 Division of Hematology Department of ... 2
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NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
36566271
DOI
10.1038/s41375-022-01802-y
Knihovny.cz E-zdroje
Recent evidence suggests that the prognostic impact of gene mutations in patients with chronic lymphocytic leukemia (CLL) may differ depending on the immunoglobulin heavy variable (IGHV) gene somatic hypermutation (SHM) status. In this study, we assessed the impact of nine recurrently mutated genes (BIRC3, EGR2, MYD88, NFKBIE, NOTCH1, POT1, SF3B1, TP53, and XPO1) in pre-treatment samples from 4580 patients with CLL, using time-to-first-treatment (TTFT) as the primary end-point in relation to IGHV gene SHM status. Mutations were detected in 1588 (34.7%) patients at frequencies ranging from 2.3-9.8% with mutations in NOTCH1 being the most frequent. In both univariate and multivariate analyses, mutations in all genes except MYD88 were associated with a significantly shorter TTFT. In multivariate analysis of Binet stage A patients, performed separately for IGHV-mutated (M-CLL) and unmutated CLL (U-CLL), a different spectrum of gene alterations independently predicted short TTFT within the two subgroups. While SF3B1 and XPO1 mutations were independent prognostic variables in both U-CLL and M-CLL, TP53, BIRC3 and EGR2 aberrations were significant predictors only in U-CLL, and NOTCH1 and NFKBIE only in M-CLL. Our findings underscore the need for a compartmentalized approach to identify high-risk patients, particularly among M-CLL patients, with potential implications for stratified management.
- MeSH
- chronická lymfatická leukemie * genetika MeSH
- fenotyp MeSH
- lidé MeSH
- mutace MeSH
- prognóza MeSH
- protein MyD88 genetika MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
36635392
DOI
10.1038/s41375-023-01813-3
Knihovny.cz E-zdroje
- Publikační typ
- tisková chyba MeSH
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