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Department of Women's and Children's ... 1 Dept of Immunology 2nd Faculty of Med... 1 Equipe 11 labellisée par la Ligue Nat... 1 Equipe 13 Centre de Recherche des Cor... 1 Group of Immune receptors of the Inna... 1 Gustave Roussy Cancer Campus Villejui... 1 INSERM U1015 CICBT507 Villejuif France 1 INSERM U1138 Paris France 1 INSERM U970 Paris France 1 Laboratory of Integrative Cancer Immu... 1 Metabolomics and Cell Biology Platfor... 1 Paris Cardiovascular Research Center ... 1 Pôle de Biologie Hôpital Européen Geo... 1 Service d'Immunologie Biologique Hôpi... 1 Sotio Prague Czech Republic 1 Université Paris Descartes Paris 5 So... 1 Université Pierre et Marie Curie Pari... 1
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Pracoviště
Department of Women's and Children's ... 1 Dept of Immunology 2nd Faculty of Med... 1 Equipe 11 labellisée par la Ligue Nat... 1 Equipe 13 Centre de Recherche des Cor... 1 Group of Immune receptors of the Inna... 1 Gustave Roussy Cancer Campus Villejui... 1 INSERM U1015 CICBT507 Villejuif France 1 INSERM U1138 Paris France 1 INSERM U970 Paris France 1 Laboratory of Integrative Cancer Immu... 1 Metabolomics and Cell Biology Platfor... 1 Paris Cardiovascular Research Center ... 1 Pôle de Biologie Hôpital Européen Geo... 1 Service d'Immunologie Biologique Hôpi... 1 Sotio Prague Czech Republic 1 Université Paris Descartes Paris 5 So... 1 Université Pierre et Marie Curie Pari... 1
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Buqué, Aitziber
Autor Buqué, Aitziber INSERM, U1138, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Université Pierre et Marie Curie/Paris VI, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Gustave Roussy Cancer Campus, Villejuif, France
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Bloy, Norma
Autor Bloy, Norma INSERM, U1138, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Université Pierre et Marie Curie/Paris VI, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Gustave Roussy Cancer Campus, Villejuif, France
- Aranda, Fernando
- Cremer, Isabelle
- Eggermont, Alexander
- Fridman, Wolf Hervé
- Fucikova, Jitka
- Galon, Jérôme
- Spisek, Radek
- Tartour, Eric
Europe PubMed Central od 2012 do Před 1 rokem
ROAD: Directory of Open Access Scholarly Resources od 2012
PubMed
27471617
DOI
10.1080/2162402x.2016.1149674
Knihovny.cz E-zdroje
Progressing malignancies establish robust immunosuppressive networks that operate both systemically and locally. In particular, as tumors escape immunosurveillance, they recruit increasing amounts of myeloid and lymphoid cells that exert pronounced immunosuppressive effects. These cells not only prevent the natural recognition of growing neoplasms by the immune system, but also inhibit anticancer immune responses elicited by chemo-, radio- and immuno therapeutic interventions. Throughout the past decade, multiple strategies have been devised to counteract the accumulation or activation of tumor-infiltrating immunosuppressive cells for therapeutic purposes. Here, we review recent preclinical and clinical advances on the use of small molecules that target the immunological tumor microenvironment for cancer therapy. These agents include inhibitors of indoleamine 2,3-dioxigenase 1 (IDO1), prostaglandin E2, and specific cytokine receptors, as well as modulators of intratumoral purinergic signaling and arginine metabolism.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.