Yeasts frequently colonize non-sterile sites in the body. The aim of the study was to determine distribution in clinical samples and antifungal susceptibility to five antifungals. From January 2013 through June 2015, 800 isolates were obtained from intensive care unit patients. Candida albicans (58.9%), Candida glabrata (20.4%), Candida krusei (8.6%), and Candida parapsilosis (3.6%) were the leading species. Majority of the C. albicans isolates were susceptible to the fluconazole. Elevated voriconazole minimal inhibitory concentrations (MICs) were observed in isolates exhibiting high fluconazole MICs, most frequently in C. glabrata. Isolates with echinocandins MICs suggesting reduced susceptibility were only sporadic cases with the exception of Trichosporon spp. The amphotericin B MICs were slightly higher for some C. krusei.
- MeSH
- amfotericin B farmakologie MeSH
- antifungální látky farmakologie MeSH
- Candida klasifikace účinky léků genetika izolace a purifikace MeSH
- flukonazol farmakologie MeSH
- fungální léková rezistence MeSH
- jednotky intenzivní péče statistika a číselné údaje MeSH
- kandidóza mikrobiologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- vorikonazol farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
