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Autor
Amant, Frédéric 1 Boll, Dorry 1 Bronsert, Peter 1 Bulten, Johan 1 Colas, Eva 1 Cornel, Karlijn M C 1 Enitec-Consortium 1 Geomini, Peggy M A J 1 Gil-Moreno, Antonio 1 Haldorsen, Ingfrid S 1 Huvila, Jutta 1 Koskas, Martin 1 Kraayenbrink, Arjan A 1 Krakstad, Camilla 1 Küsters-Vandevelde, Heidi V N 1 Lombaers, Marike S 1 Mancebo, Gemma 1 Matías-Guiu, Xavier 1 Ngo, Huy 1 Pijlman, Brenda M 1
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Pracoviště
Biomedical Research Group in Gynecolo... 1 Center for Gynecologic Oncology Amste... 1 Centre for Cancer Biomarkers Departme... 1 Department of Gynecology Catharina Ho... 1 Department of Gynecology Vall Hebron ... 1 Department of Gynecology and Obstetri... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Oncology KU Leuven 3000... 1 Department of Pathology Canisius Wilh... 1
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Autor
Amant, Frédéric 1 Boll, Dorry 1 Bronsert, Peter 1 Bulten, Johan 1 Colas, Eva 1 Cornel, Karlijn M C 1 Enitec-Consortium 1 Geomini, Peggy M A J 1 Gil-Moreno, Antonio 1 Haldorsen, Ingfrid S 1 Huvila, Jutta 1 Koskas, Martin 1 Kraayenbrink, Arjan A 1 Krakstad, Camilla 1 Küsters-Vandevelde, Heidi V N 1 Lombaers, Marike S 1 Mancebo, Gemma 1 Matías-Guiu, Xavier 1 Ngo, Huy 1 Pijlman, Brenda M 1
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Pracoviště
Biomedical Research Group in Gynecolo... 1 Center for Gynecologic Oncology Amste... 1 Centre for Cancer Biomarkers Departme... 1 Department of Gynecology Catharina Ho... 1 Department of Gynecology Vall Hebron ... 1 Department of Gynecology and Obstetri... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Oncology KU Leuven 3000... 1 Department of Pathology Canisius Wilh... 1
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Free Medical Journals od 2009
PubMed Central od 2009
Europe PubMed Central od 2009
ProQuest Central od 2009-01-01
Open Access Digital Library od 2009-01-01
Open Access Digital Library od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources od 2009
PubMed
37174070
DOI
10.3390/cancers15092605
Knihovny.cz E-zdroje
Patients with high-grade endometrial carcinoma (EC) have an increased risk of tumor spread and lymph node metastasis (LNM). Preoperative imaging and CA125 can be used in work-up. As data on cancer antigen 125 (CA125) in high-grade EC are limited, we aimed to study primarily the predictive value of CA125, and secondarily the contributive value of computed tomography (CT) for advanced stage and LNM. Patients with high-grade EC (n = 333) and available preoperative CA125 were included retrospectively. The association of CA125 and CT findings with LNM was analyzed by logistic regression. Elevated CA125 ((>35 U/mL), (35.2% (68/193)) was significantly associated with stage III-IV disease (60.3% (41/68)) compared with normal CA125 (20.8% (26/125), [p < 0.001]), and with reduced disease-specific-(DSS) (p < 0.001) and overall survival (OS) (p < 0.001). The overall accuracy of predicting LNM by CT resulted in an area under the curve (AUC) of 0.623 (p < 0.001) independent of CA125. Stratification by CA125 resulted in an AUC of 0.484 (normal), and 0.660 (elevated). In multivariate analysis elevated CA125, non-endometrioid histology, pathological deep myometrial invasion ≥50%, and cervical involvement were significant predictors of LNM, whereas suspected LNM on CT was not. This shows that elevated CA125 is a relevant independent predictor of advanced stage and outcome specifically in high-grade EC.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.