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DESAM Institute Near East University ... 1 Department of Medical Genetics Facult... 1 Department of Medical Genetics Near E... 1 Department of Molecular Biology and G... 1 Department of Physical Education Plek... 1 Department of Physical Education and ... 1 Laboratory of Genetics of Aging and L... 1 Physical Education and Sports Teachin... 1 Research Institute for Sport and Exer... 1 Research Institute of Physical Cultur... 1 Sports Science Faculty Bingol Univers... 1 Sports Science Faculty Lokman Hekim U... 1 Vocational School of Health Services ... 1
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DESAM Institute Near East University ... 1 Department of Medical Genetics Facult... 1 Department of Medical Genetics Near E... 1 Department of Molecular Biology and G... 1 Department of Physical Education Plek... 1 Department of Physical Education and ... 1 Laboratory of Genetics of Aging and L... 1 Physical Education and Sports Teachin... 1 Research Institute for Sport and Exer... 1 Research Institute of Physical Cultur... 1 Sports Science Faculty Bingol Univers... 1 Sports Science Faculty Lokman Hekim U... 1 Vocational School of Health Services ... 1
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- Demirci, Berkay
- Bulgay, Celal
- Ceylan, Halil İbrahim
- Öztürk, Mehmet Ertuğrul
- Öztürk, Deniz
- Kazan, Hasan Huseyin
- Ergun, Mehmet Ali
- Cerit, Mesut
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Semenova, Ekaterina A
Autor Semenova, Ekaterina A ORCID Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, 420138 Kazan, Russia
- Larin, Andrey K
Free Medical Journals od 2010
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PubMed
37372374
DOI
10.3390/genes14061190
Knihovny.cz E-zdroje
The α-actinin-3 (ACTN3) gene rs1815739 (C/T, R577X) polymorphism is a variant frequently associated with athletic performance among different populations. However, there is limited research on the impact of this variant on athlete status and physical performance in basketball players. Therefore, the aim of this study was twofold: (1) to determine the association of ACTN3 rs1815739 polymorphism with changes in physical performance in response to six weeks of training in elite basketball players using 30 m sprint and Yo-Yo Intermittent Recovery Test Level 2 (IR 2) tests, and (2) to compare ACTN3 genotype and allelic frequencies between elite basketball players and controls. The study included a total of 363 individuals, comprising 101 elite basketball players and 262 sedentary individuals. Genomic DNA was isolated from oral epithelial cells or leukocytes, and genotyping was performed by real-time PCR using KASP genotyping method or by microarray analysis. We found that the frequency of the ACTN3 rs1815739 XX genotype was significantly lower in basketball players compared to controls (10.9 vs. 21.4%, p = 0.023), suggesting that RR/RX genotypes were more favorable for playing basketball. Statistically significant (p = 0.045) changes were observed in Yo-Yo IRT 2 performance measurement tests in basketball players with the RR genotype only. In conclusion, our findings suggest that the carriage of the ACTN3 rs1815739 R allele may confer an advantage in basketball.
- MeSH
- aktinin * genetika MeSH
- basketbal * MeSH
- frekvence genu MeSH
- genotyp MeSH
- lidé MeSH
- polymorfismus genetický MeSH
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